SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		5 / 12 PHE A 144
VAL A  76
TYR A 212
ILE A 228
LEU A  90
 None
 1.22A 1fm4A-2cmhA:
undetectable		 1fm4A-2cmhA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 8 LEU A  77
GLY A 156
LEU A 135
TYR A 140
 None
 0.79A 1jlbA-2cmhA:
undetectable		 1jlbA-2cmhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A  62
GLY A 209
SER A 206
ALA A 171
ALA A 184
 None
 1.12A 2bm9A-2cmhA:
7.9		 2bm9A-2cmhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 8 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.92A 2eilP-2cmhA:
undetectable
2eilW-2cmhA:
undetectable		 2eilP-2cmhA:
23.63
2eilW-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 8 ALA A 245
TYR A 236
ILE A 241
TYR A 237
 None
 0.82A 2zm8A-2cmhA:
undetectable		 2zm8A-2cmhA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 8 ALA A 245
TYR A 236
ILE A 241
TYR A 237
 None
 0.82A 2zmaA-2cmhA:
undetectable		 2zmaA-2cmhA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 8 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.96A 3asoC-2cmhA:
undetectable
3asoJ-2cmhA:
undetectable		 3asoC-2cmhA:
23.63
3asoJ-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 7 PHE A 246
MET A 196
ILE A 168
TYR A 237
 None
 1.00A 3p6hA-2cmhA:
undetectable		 3p6hA-2cmhA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 8 ILE A  78
LEU A  86
MET A  65
GLY A  66
 None
 0.96A 3selX-2cmhA:
undetectable		 3selX-2cmhA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		5 / 12 ILE A 228
TYR A 237
LEU A 231
LEU A  73
HIS A 242
 None
 1.46A 3vn2A-2cmhA:
undetectable		 3vn2A-2cmhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		5 / 12 ILE A 228
TYR A 237
LEU A 231
LEU A  90
HIS A 242
 None
 1.45A 3vn2A-2cmhA:
undetectable		 3vn2A-2cmhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 6 GLY A 190
GLY A 189
ASN A 259
ILE A 154
 None
 0.90A 4fglD-2cmhA:
undetectable		 4fglD-2cmhA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 7 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.96A 5b1aC-2cmhA:
undetectable
5b1aJ-2cmhA:
undetectable		 5b1aC-2cmhA:
23.63
5b1aJ-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 7 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.91A 5b1aP-2cmhA:
undetectable
5b1aW-2cmhA:
undetectable		 5b1aP-2cmhA:
23.63
5b1aW-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 7 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.93A 5b3sC-2cmhA:
undetectable
5b3sJ-2cmhA:
undetectable		 5b3sC-2cmhA:
23.63
5b3sJ-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 7 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.93A 5b3sP-2cmhA:
undetectable		 5b3sP-2cmhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 6 ILE A 211
PHE A 192
PHE A 246
THR A  69
 None
 1.28A 5g08A-2cmhA:
undetectable		 5g08A-2cmhA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		4 / 7 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.90A 5iy5C-2cmhA:
undetectable
5iy5J-2cmhA:
undetectable		 5iy5C-2cmhA:
23.63
5iy5J-2cmhA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2cmh SPERMIDINE SYNTHASE
(Helicobacter
pylori) 		3 / 3 THR A 127
HIS A  96
ASN A 125
 None
 0.89A 5n4tA-2cmhA:
undetectable		 5n4tA-2cmhA:
21.91