SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		4 / 8 ILE A  17
ILE A  19
ILE A  27
VAL A 152
 None
 0.68A 2nniA-2cmtA:
undetectable		 2nniA-2cmtA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		4 / 8 GLY A  82
CYH A 168
GLY A  71
PHE A  60
 None
 0.99A 3ko0O-2cmtA:
undetectable
3ko0Q-2cmtA:
undetectable		 3ko0O-2cmtA:
22.58
3ko0Q-2cmtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		4 / 5 ARG A  12
LEU A 105
ILE A 165
PHE A  15
 None
 1.23A 3ln1D-2cmtA:
undetectable		 3ln1D-2cmtA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		4 / 7 PHE A 136
MET A 107
ILE A 121
VAL A 139
 None
 1.04A 3p6hA-2cmtA:
undetectable		 3p6hA-2cmtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		4 / 6 ILE A  64
PRO A  65
ILE A  19
VAL A 163
 None
 0.99A 4zj8A-2cmtA:
undetectable		 4zj8A-2cmtA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		5 / 12 GLY A 116
ILE A  85
ASN A 109
PHE A  43
LEU A 105
 None
 1.12A 5fa8A-2cmtA:
undetectable		 5fa8A-2cmtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E
(Schistosoma
mansoni) 		5 / 12 GLY A 103
VAL A 139
GLY A  71
GLY A  72
MET A 149
 None
 0.93A 6brdB-2cmtA:
undetectable		 6brdB-2cmtA:
16.67