SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		6 / 10 ASP A 231
GLY A 230
ASP A 236
GLY A 205
ILE A 197
THR A  37
 None
 1.48A 1t7iA-2cn1A:
undetectable		 1t7iA-2cn1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		3 / 3 GLU A 273
GLU A 276
LEU A 225
 None
 0.69A 1v8bB-2cn1A:
3.4		 1v8bB-2cn1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		5 / 10 LEU A 225
ARG A  17
LEU A 269
TYR A 249
THR A  42
 None
 1.31A 1zucA-2cn1A:
0.6		 1zucA-2cn1A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		3 / 3 SER A 228
HIS A  57
ASP A 158
 None
 0.83A 2oxtA-2cn1A:
undetectable		 2oxtA-2cn1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		4 / 4 SER A 228
GLY A 230
HIS A  57
ASP A 158
 None
 0.90A 2oxtC-2cn1A:
undetectable		 2oxtC-2cn1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		4 / 6 LEU A 120
SER A 153
PHE A  39
ASP A  38
 None
 0.99A 2vn1B-2cn1A:
undetectable		 2vn1B-2cn1A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		5 / 10 GLU A 162
ARG A 165
ILE A 164
GLY A 168
LEU A 275
 None
 1.33A 3adsA-2cn1A:
undetectable		 3adsA-2cn1A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		5 / 11 LEU A 225
LEU A 282
ALA A 278
ASN A 137
VAL A 149
 None
 1.27A 3e22B-2cn1A:
4.7		 3e22B-2cn1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		5 / 11 LEU A 282
ALA A 278
LEU A 275
ASN A 137
VAL A 149
 None
 1.30A 3e22B-2cn1A:
4.7		 3e22B-2cn1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		5 / 11 LEU A 225
LEU A 282
ALA A 278
ASN A 137
VAL A 149
 None
 1.29A 3e22D-2cn1A:
5.3		 3e22D-2cn1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		3 / 3 HIS A 107
GLY A 155
ILE A 156
 None
 0.53A 4k50A-2cn1A:
undetectable		 4k50A-2cn1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		3 / 3 HIS A 107
GLY A 155
ILE A 156
 None
 0.52A 4k50I-2cn1A:
undetectable		 4k50I-2cn1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III
(Homo
sapiens) 		6 / 10 ASP A 231
GLY A 230
ASP A 236
GLY A 205
ILE A 197
THR A  37
 None
 1.48A 4njtB-2cn1A:
undetectable		 4njtB-2cn1A:
19.75