SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cnd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		4 / 8 LEU A  23
GLY A 145
ILE A 148
VAL A  27
 None
 0.73A 1d4sB-2cndA:
undetectable		 1d4sB-2cndA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 9 ALA A 241
GLY A 147
ILE A 148
VAL A 221
ILE A 252
 None
 1.07A 2q5kA-2cndA:
undetectable		 2q5kA-2cndA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 10 ALA A 241
GLY A 147
ILE A 148
VAL A 221
ILE A 252
 None
 0.99A 3ekyA-2cndA:
undetectable		 3ekyA-2cndA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 12 VAL A 230
VAL A 225
ILE A 252
VAL A 221
VAL A 203
 None
 1.25A 3iw1A-2cndA:
undetectable		 3iw1A-2cndA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 10 VAL A 200
ASP A 188
TYR A 173
ILE A 181
ILE A 148
 None
 1.42A 3vriA-2cndA:
2.0
3vriC-2cndA:
undetectable		 3vriA-2cndA:
20.27
3vriC-2cndA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		4 / 6 THR A 149
CYH A 143
GLY A 144
ILE A 181
 FAD  A 271 (-2.7A)
None
None
None
 1.01A 3w9tF-2cndA:
undetectable		 3w9tF-2cndA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 12 ALA A 174
VAL A 172
PHE A 267
ASN A 255
SER A 253
 None
 1.21A 4c49A-2cndA:
undetectable		 4c49A-2cndA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 11 LEU A  17
LEU A  78
LEU A 101
MET A  97
VAL A 112
 None
 1.16A 4x20D-2cndA:
undetectable		 4x20D-2cndA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		4 / 5 LEU A 240
PHE A 267
ILE A 142
ILE A 252
 None
 0.94A 5dzk4-2cndA:
undetectable
5dzkg-2cndA:
undetectable
5dzkm-2cndA:
undetectable
5dzkn-2cndA:
undetectable		 5dzk4-2cndA:
1.09
5dzkg-2cndA:
20.00
5dzkm-2cndA:
22.34
5dzkn-2cndA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		4 / 7 LEU A 187
TYR A 152
THR A  65
LEU A 198
 None
None
FAD  A 271 (-4.3A)
None
 1.11A 5jq7B-2cndA:
0.0		 5jq7B-2cndA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		3 / 3 VAL A 218
SER A 217
TRP A 214
 None
 0.97A 5jwaA-2cndA:
2.4		 5jwaA-2cndA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		3 / 3 HIS A  88
LYS A  90
PHE A  91
 FAD  A 271 (-4.0A)
None
FAD  A 271 (-3.5A)
 1.14A 5klaA-2cndA:
undetectable		 5klaA-2cndA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		4 / 4 VAL A 268
LEU A 139
ASN A 265
ASP A 262
 None
 1.39A 5vcyA-2cndA:
undetectable		 5vcyA-2cndA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		4 / 6 LEU A  34
PHE A  32
PHE A  76
LEU A  41
 None
 1.21A 5x19P-2cndA:
undetectable		 5x19P-2cndA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2cnd NADH-DEPENDENT
NITRATE REDUCTASE
(Zea
mays) 		5 / 12 ARG A 160
GLY A  42
GLY A  74
ILE A  73
LEU A  78
 None
 0.86A 6dh0B-2cndA:
undetectable		 6dh0B-2cndA:
16.52