SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2coc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KXH_A_ACRA598_2 (ALPHA-AMYLASE)	2coc	FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3 (Homo sapiens)	3 / 3	TRP A 75 TYR A 85 LEU A 16	None	0.88A	1kxhA-2cocA: undetectable	1kxhA-2cocA: 14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_A_ROFA901_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2coc	FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3 (Homo sapiens)	3 / 3	ASP A 46 LEU A 49 GLN A 82	None	0.76A	3g4lA-2cocA: undetectable	3g4lA-2cocA: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H0A_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2coc	FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ALA A 88 GLN A 94 LEU A 98 LEU A 93 LEU A 38	None	0.76A	3h0aA-2cocA: undetectable	3h0aA-2cocA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2coc	FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ALA A 28 SER A 111 THR A 100 LEU A 101 ALA A 104	None	1.11A	6djzC-2cocA: undetectable	6djzC-2cocA: 21.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KXH_A_ACRA598_2","ALPHA-AMYLASE","2coc","FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3","Homo sapiens",3,"TRP A  75;TYR A  85;LEU A  16","None","0.88A","1kxhA-2cocA:undetectable","1kxhA-2cocA:14.55"],["3G4L_A_ROFA901_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","2coc","FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3","Homo sapiens",3,"ASP A  46;LEU A  49;GLN A  82","None","0.76A","3g4lA-2cocA:undetectable","3g4lA-2cocA:15.57"],["3H0A_A_9RAA500_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2coc","FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3","Homo sapiens",5,"ALA A  88;GLN A  94;LEU A  98;LEU A  93;LEU A  38","None","0.76A","3h0aA-2cocA:undetectable","3h0aA-2cocA:19.56"],["6DJZ_C_GMJC301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","2coc","FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3","Homo sapiens",5,"ALA A  28;SER A 111;THR A 100;LEU A 101;ALA A 104","None","1.11A","6djzC-2cocA:undetectable","6djzC-2cocA:21.27"]]