SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 HIS A  67
ASP A  68
LYS A  87
HIS A  33
PHE A  95
 NI  A 601 (-3.5A)
NI  A 601 (-2.8A)
None
NI  A 601 (-3.4A)
None
 1.43A 1d4fB-2cqzA:
undetectable		 1d4fB-2cqzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A  11
VAL A   8
VAL A  94
VAL A  98
 None
 0.89A 1iwiA-2cqzA:
undetectable		 1iwiA-2cqzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A  11
VAL A   8
VAL A  94
VAL A  98
 None
 0.91A 1t86A-2cqzA:
undetectable		 1t86A-2cqzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 158
ARG A  54
VAL A  57
MET A  63
 None
 1.04A 2qd2A-2cqzA:
undetectable		 2qd2A-2cqzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A 130
TYR A 133
GLN A 134
 None
 0.68A 2wekA-2cqzA:
undetectable		 2wekA-2cqzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A  11
VAL A   8
VAL A  94
VAL A  98
 None
 0.90A 2z97A-2cqzA:
undetectable		 2z97A-2cqzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A  11
VAL A   8
VAL A  94
VAL A  98
 None
 0.87A 2zujA-2cqzA:
undetectable		 2zujA-2cqzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A 153
LEU A 166
THR A  41
LEU A  44
 None
 1.03A 3ablA-2cqzA:
0.2
3ablJ-2cqzA:
undetectable		 3ablA-2cqzA:
14.56
3ablJ-2cqzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A  44
LEU A 166
GLN A 118
ILE A  55
 None
 0.92A 3cldB-2cqzA:
2.9		 3cldB-2cqzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 166
VAL A 169
ILE A  40
LEU A  44
 None
 0.86A 4qrcA-2cqzA:
undetectable		 4qrcA-2cqzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A  11
ASP A  32
ILE A   5
 None
 0.63A 4xi3D-2cqzA:
undetectable		 4xi3D-2cqzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A 153
LEU A 166
THR A  41
LEU A  44
 None
 0.98A 5b3sA-2cqzA:
undetectable
5b3sJ-2cqzA:
undetectable		 5b3sA-2cqzA:
14.56
5b3sJ-2cqzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A 153
LEU A 166
THR A  41
LEU A  44
 None
 0.99A 5iy5A-2cqzA:
0.3
5iy5J-2cqzA:
undetectable		 5iy5A-2cqzA:
14.56
5iy5J-2cqzA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ILE A 129
ALA A 149
ILE A 150
ILE A 122
LEU A 166
 None
 0.94A 5mvmA-2cqzA:
undetectable
5mvmE-2cqzA:
undetectable		 5mvmA-2cqzA:
17.42
5mvmE-2cqzA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A 153
LEU A 166
THR A  41
LEU A  44
 None
 0.97A 5xdqA-2cqzA:
0.3
5xdqJ-2cqzA:
undetectable		 5xdqA-2cqzA:
14.56
5xdqJ-2cqzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A 153
LEU A 166
THR A  41
LEU A  44
 None
 0.97A 5zcpA-2cqzA:
1.2
5zcpJ-2cqzA:
undetectable		 5zcpA-2cqzA:
14.56
5zcpJ-2cqzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2cqz 177AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ASP A 124
ARG A  16
GLU A  71
ASP A  76
 NI  A 601 (-2.7A)
NI  A 601 ( 4.3A)
None
None
 1.29A 6mn5E-2cqzA:
undetectable		 6mn5E-2cqzA:
18.86