SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 2cr4 SH3 DOMAIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 10 LEU A 113
VAL A  93
GLY A  94
LEU A  60
TYR A 100
 None
 1.42A 3qipA-2cr4A:
undetectable		 3qipA-2cr4A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2cr4 SH3 DOMAIN-BINDING
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A 113
VAL A  93
GLY A  94
LEU A  60
TYR A 100
 None
 1.39A 5hbmA-2cr4A:
undetectable		 5hbmA-2cr4A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2cr4 SH3 DOMAIN-BINDING
PROTEIN 2
(Homo
sapiens) 		4 / 5 PHE A  90
VAL A  59
PRO A 106
VAL A  88
 None
 1.24A 6ekzA-2cr4A:
undetectable		 6ekzA-2cr4A:
21.36