SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2cr5 REPRODUCTION 8
(Mus
musculus) 		5 / 9 LEU A  93
LEU A  74
LEU A  65
LEU A  82
ILE A  87
 None
 1.21A 2f7aB-2cr5A:
undetectable		 2f7aB-2cr5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2cr5 REPRODUCTION 8
(Mus
musculus) 		4 / 5 VAL A  26
LEU A  49
VAL A  48
PHE A  40
 None
 1.05A 4lb0B-2cr5A:
undetectable		 4lb0B-2cr5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cr5 REPRODUCTION 8
(Mus
musculus) 		4 / 8 ASN A  94
LEU A  74
VAL A  26
ILE A  87
 None
 0.83A 4r38D-2cr5A:
undetectable		 4r38D-2cr5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2cr5 REPRODUCTION 8
(Mus
musculus) 		5 / 9 LEU A  82
ILE A  87
GLY A  86
LEU A  49
LEU A  65
 None
 0.95A 5o96A-2cr5A:
undetectable
5o96B-2cr5A:
undetectable		 5o96A-2cr5A:
17.70
5o96B-2cr5A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2cr5 REPRODUCTION 8
(Mus
musculus) 		5 / 12 ASN A  45
GLY A  79
VAL A  26
LEU A  93
GLY A  86
 None
 1.00A 5vooB-2cr5A:
undetectable		 5vooB-2cr5A:
17.71