SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2crm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		4 / 8 ARG A  89
SER A 106
SER A  61
ASN A  62
 None
 0.95A 1hwkA-2crmA:
undetectable		 1hwkA-2crmA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		4 / 8 ARG A  89
SER A 106
SER A  61
ASN A  62
 None
 0.91A 1hwkC-2crmA:
undetectable		 1hwkC-2crmA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		4 / 8 ARG A  89
SER A 106
SER A  61
ASN A  62
 None
 0.91A 1hwkD-2crmA:
undetectable		 1hwkD-2crmA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		3 / 3 VAL A  55
VAL A 103
TRP A  39
 None
 0.97A 1w5uC-2crmA:
undetectable
1w5uD-2crmA:
undetectable		 1w5uC-2crmA:
10.39
1w5uD-2crmA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		4 / 6 HIS A  77
MET A  57
VAL A  92
LEU A  90
 None
 1.22A 5xdhA-2crmA:
undetectable
5xdhC-2crmA:
undetectable		 5xdhA-2crmA:
23.48
5xdhC-2crmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		4 / 5 HIS A  77
MET A  57
VAL A  92
LEU A  90
 None
 1.21A 5xdhB-2crmA:
undetectable		 5xdhB-2crmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2crm FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens) 		4 / 5 HIS A  77
MET A  57
VAL A  92
LEU A  90
 None
 1.25A 5xdhD-2crmA:
undetectable		 5xdhD-2crmA:
23.48