SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2crw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		4 / 5 GLU A 122
ALA A 117
SER A 114
HIS A 101
 None
 1.05A 1errA-2crwA:
undetectable
1errB-2crwA:
undetectable		 1errA-2crwA:
20.87
1errB-2crwA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLU A 122
ALA A 117
SER A 114
 None
 0.53A 1errB-2crwA:
undetectable		 1errB-2crwA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		4 / 7 SER A  67
TYR A  47
VAL A  49
ILE A  69
 None
 1.25A 2x45B-2crwA:
undetectable		 2x45B-2crwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		4 / 7 SER A  67
TYR A  47
VAL A  49
ILE A  69
 None
 1.25A 2x45C-2crwA:
undetectable		 2x45C-2crwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		3 / 3 THR A  46
SER A  67
PHE A  33
 None
 0.77A 3d4sA-2crwA:
undetectable		 3d4sA-2crwA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		5 / 10 CYH A  55
ASP A  34
CYH A  32
GLY A  36
ALA A  37
 ZN  A 401 (-2.3A)
None
ZN  A 401 (-2.3A)
None
ZN  A 401 ( 4.6A)
 1.23A 3ucjA-2crwA:
undetectable		 3ucjA-2crwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		4 / 8 SER A  76
ILE A  16
ASN A  77
ASP A  10
 None
 1.11A 4d39A-2crwA:
undetectable		 4d39A-2crwA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens) 		3 / 3 ARG A  70
ASP A  75
TRP A  78
 None
 1.16A 4xdqA-2crwA:
undetectable		 4xdqA-2crwA:
19.69