SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2cry KIN OF IRRE-LIKE
PROTEIN 3
(Homo
sapiens) 		3 / 3 ILE A 106
ILE A  91
THR A 104
 None
 0.64A 1rg7A-2cryA:
undetectable		 1rg7A-2cryA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2cry KIN OF IRRE-LIKE
PROTEIN 3
(Homo
sapiens) 		4 / 5 ILE A  37
SER A  39
PHE A 100
PRO A  41
 None
 1.40A 3bjwC-2cryA:
undetectable		 3bjwC-2cryA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2cry KIN OF IRRE-LIKE
PROTEIN 3
(Homo
sapiens) 		4 / 7 ILE A 106
ILE A 107
THR A 104
ILE A  17
 None
 0.91A 5murB-2cryA:
undetectable		 5murB-2cryA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2cry KIN OF IRRE-LIKE
PROTEIN 3
(Homo
sapiens) 		3 / 3 GLY A 101
ASP A 103
ILE A  37
 None
 0.45A 6dgxB-2cryA:
undetectable		 6dgxB-2cryA:
25.45