SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cs0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING
(Homo
sapiens) 		4 / 4 THR A 106
LEU A 105
VAL A  90
LEU A  89
 None
 1.03A 1fbmB-2cs0A:
undetectable		 1fbmB-2cs0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING
(Homo
sapiens) 		3 / 3 THR A 106
LEU A 105
VAL A  90
 None
 0.66A 1mz9E-2cs0A:
undetectable		 1mz9E-2cs0A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING
(Homo
sapiens) 		4 / 7 LEU A  41
ASP A  27
SER A  54
THR A  52
 None
 1.29A 3dzgB-2cs0A:
undetectable		 3dzgB-2cs0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING
(Homo
sapiens) 		3 / 3 GLY A 115
PRO A 116
GLN A  12
 None
 0.47A 4oltB-2cs0A:
0.6		 4oltB-2cs0A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING
(Homo
sapiens) 		3 / 3 GLY A 115
PRO A 116
GLN A  12
 None
 0.58A 4qwpB-2cs0A:
0.8		 4qwpB-2cs0A:
18.15