SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cs5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FWD_A_BO2A801_1 (TTC1975 PEPTIDASE)	2cs5	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4 (Homo sapiens)	5 / 9	VAL A 67 VAL A 68 VAL A 83 ILE A 70 GLY A 72	None	1.08A	4fwdA-2cs5A: undetectable	4fwdA-2cs5A: 11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HAJ_A_DXCA75_0 (PPCA)	2cs5	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4 (Homo sapiens)	4 / 7	ILE A 70 LEU A 98 PHE A 29 GLY A 27	None	0.96A	4hajA-2cs5A: undetectable	4hajA-2cs5A: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NQA_A_9CRA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2cs5	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4 (Homo sapiens)	5 / 11	ILE A 87 ALA A 89 LEU A 98 VAL A 33 HIS A 80	None	1.12A	4nqaA-2cs5A: undetectable	4nqaA-2cs5A: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTW_A_DB8A1101_2 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3)	2cs5	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4 (Homo sapiens)	3 / 3	LEU A 56 LEU A 100 ASN A 62	None	0.71A	4otwA-2cs5A: undetectable	4otwA-2cs5A: 19.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4FWD_A_BO2A801_1","TTC1975 PEPTIDASE","2cs5","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4","Homo sapiens",5,"VAL A  67;VAL A  68;VAL A  83;ILE A  70;GLY A  72","None","1.08A","4fwdA-2cs5A:undetectable","4fwdA-2cs5A:11.15"],["4HAJ_A_DXCA75_0","PPCA","2cs5","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4","Homo sapiens",4,"ILE A  70;LEU A  98;PHE A  29;GLY A  27","None","0.96A","4hajA-2cs5A:undetectable","4hajA-2cs5A:20.69"],["4NQA_A_9CRA501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2cs5","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4","Homo sapiens",5,"ILE A  87;ALA A  89;LEU A  98;VAL A  33;HIS A  80","None","1.12A","4nqaA-2cs5A:undetectable","4nqaA-2cs5A:16.87"],["4OTW_A_DB8A1101_2","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3","2cs5","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 4","Homo sapiens",3,"LEU A  56;LEU A 100;ASN A  62","None","0.71A","4otwA-2cs5A:undetectable","4otwA-2cs5A:19.32"]]