SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2csd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 243
ARG A 151
ASP A 153
GLU A  74
ARG A 102
 None
 1.44A 1agmA-2csdA:
undetectable		 1agmA-2csdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 243
ARG A 151
ASP A 153
GLU A  74
ARG A 102
 None
 1.44A 1agmA-2csdA:
undetectable		 1agmA-2csdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 219
ARG A 151
TYR A 149
THR A  96
 None
 1.45A 1ceaA-2csdA:
undetectable
1ceaB-2csdA:
undetectable		 1ceaA-2csdA:
12.82
1ceaB-2csdA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 243
ARG A 151
ASP A 153
GLU A  74
ARG A 102
 None
 1.39A 1lf9A-2csdA:
undetectable		 1lf9A-2csdA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ILE A 225
LEU A 228
VAL A 232
 None
 0.48A 1mz9B-2csdA:
undetectable		 1mz9B-2csdA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.47A 1tz8D-2csdA:
undetectable		 1tz8D-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 CYH A  68
PRO A  72
THR A  63
SER A  65
 None
 1.24A 1ymxA-2csdA:
undetectable		 1ymxA-2csdA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 243
ARG A 151
ASP A 153
GLU A  74
ARG A 102
 None
 1.36A 2f6dA-2csdA:
undetectable		 2f6dA-2csdA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 MET A 325
PRO A 330
VAL A  85
GLY A  84
 None
 1.09A 2qd3A-2csdA:
undetectable		 2qd3A-2csdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 7 SER A  69
LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.38A 3cfqA-2csdA:
undetectable
3cfqB-2csdA:
undetectable		 3cfqA-2csdA:
12.77
3cfqB-2csdA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.12A 3k39B-2csdA:
undetectable		 3k39B-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.14A 3k39C-2csdA:
undetectable		 3k39C-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.13A 3k39D-2csdA:
undetectable		 3k39D-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.15A 3k39I-2csdA:
undetectable		 3k39I-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.13A 3k39J-2csdA:
undetectable		 3k39J-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.12A 3k39K-2csdA:
undetectable		 3k39K-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ASP A 182
ARG A 442
ARG A 231
GLU A 435
GLU A 412
 None
 1.14A 3k39L-2csdA:
undetectable		 3k39L-2csdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 PHE A 374
TYR A 402
LEU A 353
 None
 0.80A 3keeB-2csdA:
undetectable		 3keeB-2csdA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.14A 3mssC-2csdA:
undetectable		 3mssC-2csdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 8 TYR A 103
LEU A  94
ALA A 382
SER A 222
SER A 227
 None
 1.38A 3rodA-2csdA:
undetectable		 3rodA-2csdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 9 TYR A 103
LEU A  94
ALA A 382
SER A 222
SER A 227
 None
 1.48A 3rodB-2csdA:
0.0		 3rodB-2csdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 PHE A 374
TYR A 402
LEU A 353
 None
 0.71A 3sueB-2csdA:
undetectable		 3sueB-2csdA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.40A 3vm4A-2csdA:
undetectable		 3vm4A-2csdA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 7 LYS A  28
LEU A 254
LEU A  62
SER A  65
SER A  69
 None
 1.33A 4ikjA-2csdA:
undetectable
4ikjB-2csdA:
undetectable		 4ikjA-2csdA:
13.15
4ikjB-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 8 SER A  69
LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.34A 4ikjA-2csdA:
undetectable
4ikjB-2csdA:
undetectable		 4ikjA-2csdA:
13.15
4ikjB-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 8 LYS A  28
LEU A 254
LEU A  62
SER A  65
SER A  69
 None
 1.36A 4ikkA-2csdA:
undetectable
4ikkB-2csdA:
undetectable		 4ikkA-2csdA:
13.15
4ikkB-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 7 SER A  69
LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.34A 4ikkA-2csdA:
undetectable
4ikkB-2csdA:
undetectable		 4ikkA-2csdA:
13.15
4ikkB-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ARG A 112
ASP A 124
ASP A 284
 None
 0.87A 4kicB-2csdA:
undetectable		 4kicB-2csdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 LYS A 134
ARG A  37
GLU A 291
ARG A 108
 None
 1.24A 4kr4C-2csdA:
undetectable		 4kr4C-2csdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 HIS A  56
VAL A 162
LEU A  61
 None
 0.65A 4m2vA-2csdA:
undetectable		 4m2vA-2csdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 138
ASN A 136
LEU A 146
VAL A 106
 None
 1.12A 4okbA-2csdA:
undetectable		 4okbA-2csdA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.08A 4ph9A-2csdA:
undetectable		 4ph9A-2csdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 437
VAL A 419
LEU A 413
GLY A 456
LEU A 463
 None
 1.07A 4ph9B-2csdA:
undetectable		 4ph9B-2csdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 1.04A 4pwjA-2csdA:
undetectable		 4pwjA-2csdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 1.00A 4pwjB-2csdA:
undetectable		 4pwjB-2csdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 GLU A 389
ARG A 429
TYR A 402
GLU A 425
 None
 1.09A 4zz8A-2csdA:
undetectable		 4zz8A-2csdA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.98A 5bojB-2csdA:
undetectable		 5bojB-2csdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 THR A 508
ASP A 509
ALA A 510
 None
 0.00A 5g5gB-2csdA:
undetectable		 5g5gB-2csdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 GLY A 224
GLU A 185
GLU A 435
LEU A 381
GLU A 412
 None
 1.25A 5gsmA-2csdA:
undetectable		 5gsmA-2csdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 GLY A 224
GLU A 185
GLU A 435
LEU A 381
GLU A 412
 None
 1.26A 5gsmB-2csdA:
undetectable		 5gsmB-2csdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 GLY A 420
PRO A 434
THR A 414
THR A 423
 None
 1.04A 5h5fA-2csdA:
undetectable		 5h5fA-2csdA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 225
GLY A 224
TYR A 226
HIS A 200
GLU A 202
 None
 1.37A 5igwA-2csdA:
3.6		 5igwA-2csdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.27A 5oj0A-2csdA:
undetectable		 5oj0A-2csdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.71A 5qgkA-2csdA:
undetectable		 5qgkA-2csdA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.76A 5qgrA-2csdA:
undetectable		 5qgrA-2csdA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.94A 6e43A-2csdA:
undetectable		 6e43A-2csdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.93A 6e43B-2csdA:
undetectable		 6e43B-2csdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.95A 6e43C-2csdA:
undetectable		 6e43C-2csdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.91A 6e43D-2csdA:
undetectable		 6e43D-2csdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2csd TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
PRO A 180
ILE A 181
GLU A 185
 None
 1.22A 6h7uA-2csdA:
undetectable		 6h7uA-2csdA:
21.17