SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2csn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 11 PHE A 208
ILE A 132
HIS A 123
ILE A 122
PHE A 137
None
1.39A 1fkfA-2csnA:
undetectable
1fkfA-2csnA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
4 / 5 THR A 181
LEU A 178
LYS A 229
TYR A 230
None
None
SO4  A 302 ( 4.2A)
None
1.28A 1gtiF-2csnA:
undetectable
1gtiF-2csnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
4 / 7 GLU A 291
PHE A 103
MET A 115
ALA A 117
None
1.30A 1linA-2csnA:
undetectable
1linA-2csnA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
8 / 12 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
GLY A  89
LEU A 138
ASP A 154
CKI  A 300 (-3.6A)
None
None
None
None
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
1.30A 1m17A-2csnA:
22.7
1m17A-2csnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 11 PHE A 208
ILE A 132
HIS A 123
ILE A 122
PHE A 137
None
1.33A 1tcoC-2csnA:
undetectable
1tcoC-2csnA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 11 PHE A 208
ILE A 132
HIS A 123
ILE A 122
PHE A 137
None
1.40A 2fkeA-2csnA:
undetectable
2fkeA-2csnA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 8 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
CKI  A 300 (-3.6A)
None
None
None
None
0.76A 3lfaA-2csnA:
18.4
3lfaA-2csnA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
3 / 3 GLU A  55
LEU A  83
LEU A  87
None
0.78A 3ohtA-2csnA:
13.2
3ohtA-2csnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
3 / 3 GLU A  55
LEU A  83
LEU A  87
None
0.76A 3ohtB-2csnA:
4.0
3ohtB-2csnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
7 / 12 ILE A  18
GLY A  21
GLY A  24
ALA A  39
LYS A  41
LEU A 138
ASP A 154
CKI  A 300 (-4.1A)
None
None
CKI  A 300 (-3.6A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
0.77A 3v5wA-2csnA:
24.3
3v5wA-2csnA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
6 / 10 ILE A  18
ALA A  39
LEU A  88
GLY A  89
LEU A 138
ASP A 154
CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
CKI  A 300 (-4.0A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
1.36A 4ks8A-2csnA:
24.5
4ks8A-2csnA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
6 / 10 ILE A  18
ALA A  39
VAL A 153
LEU A  88
GLY A  89
LEU A 138
CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
CKI  A 300 (-4.1A)
CKI  A 300 (-4.0A)
None
CKI  A 300 (-4.4A)
1.30A 4ks8A-2csnA:
24.5
4ks8A-2csnA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 12 ALA A 111
ALA A 112
GLN A 114
PHE A 137
HIS A 206
None
1.17A 4nqaH-2csnA:
undetectable
4nqaH-2csnA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
7 / 12 GLY A  19
GLY A  21
GLY A  24
ALA A  39
LYS A  41
LEU A 138
ASP A 154
CKI  A 300 ( 3.8A)
None
None
CKI  A 300 (-3.6A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
0.62A 4otiA-2csnA:
12.6
4otiA-2csnA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
6 / 11 ILE A  18
ALA A  39
LYS A  41
GLU A  55
LEU A 138
ASP A 154
CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
None
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
0.86A 4qmsA-2csnA:
25.6
4qmsA-2csnA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 10 ILE A  18
ALA A  39
LYS A  41
LEU A  87
LEU A 138
CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
None
None
CKI  A 300 (-4.4A)
0.41A 4rz7A-2csnA:
23.3
4rz7A-2csnA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
7 / 12 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
GLY A  89
LEU A 138
CKI  A 300 (-3.6A)
None
None
None
None
None
CKI  A 300 (-4.4A)
1.27A 4wkqA-2csnA:
22.3
4wkqA-2csnA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
3 / 3 GLU A  43
LYS A  41
ASN A  81
None
1.05A 4y1dA-2csnA:
undetectable
4y1dD-2csnA:
undetectable
4y1dA-2csnA:
21.36
4y1dD-2csnA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 10 ALA A  39
ILE A  85
GLY A  89
LEU A 138
ASP A 154
CKI  A 300 (-3.6A)
CKI  A 300 ( 4.5A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
1.13A 5ajqB-2csnA:
21.9
5ajqB-2csnA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 7 GLY A  19
GLY A  21
SER A  22
PHE A  23
LYS A  41
CKI  A 300 ( 3.8A)
None
None
None
None
1.25A 5izfA-2csnA:
23.6
5izfA-2csnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
4 / 7 GLY A  19
GLY A  21
SER A  22
LYS A  41
CKI  A 300 ( 3.8A)
None
None
None
0.43A 5j5xA-2csnA:
23.7
5j5xA-2csnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
5 / 8 ALA A  39
GLU A  55
ILE A  85
LEU A 138
ASP A 154
CKI  A 300 (-3.6A)
None
CKI  A 300 ( 4.5A)
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
0.85A 5owrA-2csnA:
20.4
5owrA-2csnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
6 / 12 ALA A  39
LYS A  41
GLU A  55
LEU A  83
GLY A  89
PRO A  90
CKI  A 300 (-3.6A)
None
None
None
None
None
0.84A 5vcvA-2csnA:
21.8
5vcvA-2csnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
8 / 12 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
GLY A  89
LEU A 138
ASP A 154
CKI  A 300 (-3.6A)
None
None
None
None
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
1.02A 5y7zB-2csnA:
23.9
5y7zB-2csnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)
2csn CASEIN KINASE-1
(Schizosaccharomy
ces
pombe)
4 / 5 LEU A  62
CYH A  65
THR A  66
GLY A  67
None
1.25A 6gtqA-2csnA:
undetectable
6gtqA-2csnA:
19.54