SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cso PLECKSTRIN
(Homo
sapiens) 		4 / 6 PHE A 101
ASN A  99
ILE A  72
GLY A  69
 None
 0.94A 1oniA-2csoA:
undetectable
1oniB-2csoA:
undetectable		 1oniA-2csoA:
21.38
1oniB-2csoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cso PLECKSTRIN
(Homo
sapiens) 		4 / 6 PHE A 101
ASN A  99
ILE A  72
GLY A  69
 None
 0.94A 1oniD-2csoA:
undetectable
1oniF-2csoA:
undetectable		 1oniD-2csoA:
21.38
1oniF-2csoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2cso PLECKSTRIN
(Homo
sapiens) 		4 / 8 GLU A 119
GLU A  34
GLY A 115
SER A 114
 None
 1.01A 4f93B-2csoA:
undetectable		 4f93B-2csoA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2cso PLECKSTRIN
(Homo
sapiens) 		4 / 5 PHE A  44
PHE A 108
LEU A  77
PRO A 100
 None
 1.33A 4o8zA-2csoA:
undetectable		 4o8zA-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2cso PLECKSTRIN
(Homo
sapiens) 		4 / 7 THR A  49
LEU A  70
VAL A  63
GLU A  79
 None
 1.09A 5tudA-2csoA:
undetectable		 5tudA-2csoA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cso PLECKSTRIN
(Homo
sapiens) 		5 / 10 SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
 None
 1.37A 6dlzB-2csoA:
undetectable
6dlzC-2csoA:
undetectable		 6dlzB-2csoA:
18.60
6dlzC-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cso PLECKSTRIN
(Homo
sapiens) 		5 / 11 ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
 None
 1.37A 6dlzA-2csoA:
undetectable
6dlzD-2csoA:
undetectable		 6dlzA-2csoA:
18.60
6dlzD-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cso PLECKSTRIN
(Homo
sapiens) 		5 / 10 SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
 None
 1.37A 6dm1B-2csoA:
undetectable
6dm1C-2csoA:
undetectable		 6dm1B-2csoA:
18.60
6dm1C-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cso PLECKSTRIN
(Homo
sapiens) 		5 / 11 ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
 None
 1.36A 6dm1A-2csoA:
undetectable
6dm1D-2csoA:
undetectable		 6dm1A-2csoA:
18.60
6dm1D-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cso PLECKSTRIN
(Homo
sapiens) 		5 / 10 SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
 None
 1.38A 6dm2B-2csoA:
undetectable
6dm2C-2csoA:
undetectable		 6dm2B-2csoA:
18.60
6dm2C-2csoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cso PLECKSTRIN
(Homo
sapiens) 		5 / 10 ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
 None
 1.39A 6dm2A-2csoA:
undetectable
6dm2D-2csoA:
undetectable		 6dm2A-2csoA:
18.60
6dm2D-2csoA:
18.60