SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2csu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ALA A 360
LEU A 363
VAL A 345
MET A 299
 None
 0.92A 1hk2A-2csuA:
undetectable		 1hk2A-2csuA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 188
ILE A 125
ILE A 180
PHE A   6
ILE A 155
 None
 0.99A 1qhyA-2csuA:
3.9		 1qhyA-2csuA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 113
GLU A 110
GLU A 109
ILE A  94
 None
 0.97A 1qvtA-2csuA:
undetectable		 1qvtA-2csuA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ALA A  12
ILE A 125
VAL A  58
LEU A  31
VAL A  27
 None
 1.18A 1rv7A-2csuA:
undetectable
1rv7B-2csuA:
undetectable		 1rv7A-2csuA:
13.25
1rv7B-2csuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 345
LEU A 423
ALA A 408
ALA A 360
VAL A 397
 None
 1.14A 1sa1A-2csuA:
undetectable
1sa1B-2csuA:
2.7		 1sa1A-2csuA:
23.09
1sa1B-2csuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 345
LEU A 423
ALA A 408
ALA A 360
VAL A 397
 None
 1.14A 1sa1C-2csuA:
undetectable
1sa1D-2csuA:
2.8		 1sa1C-2csuA:
23.09
1sa1D-2csuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 SER A 287
GLY A 427
HIS A 136
ASP A 138
 None
 1.10A 2oxtC-2csuA:
4.9		 2oxtC-2csuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 125
PHE A   6
ALA A 205
LEU A 208
ILE A 180
 None
 1.09A 2xkwB-2csuA:
undetectable		 2xkwB-2csuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A 222
VAL A 213
PHE A 190
VAL A 226
 None
 0.94A 3fhxB-2csuA:
3.1		 3fhxB-2csuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A 264
VAL A 270
ILE A 210
LEU A 208
PHE A 219
 None
 1.31A 3fl9H-2csuA:
2.1		 3fl9H-2csuA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 TYR A  40
ASP A  66
ASP A   3
 None
 0.91A 3ou6B-2csuA:
4.7		 3ou6B-2csuA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A  14
LYS A  90
LYS A   9
GLY A  10
 None
 1.08A 3sj0X-2csuA:
undetectable		 3sj0X-2csuA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  11
GLY A  91
ILE A 125
ILE A  69
LEU A   2
 None
 0.85A 3uj6A-2csuA:
4.7		 3uj6A-2csuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A  77
CYH A  84
ILE A  94
ILE A  14
 None
 0.89A 4afgD-2csuA:
undetectable
4afgE-2csuA:
undetectable		 4afgD-2csuA:
20.50
4afgE-2csuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A  13
CYH A  84
VAL A  42
ILE A  70
 None
 1.09A 4aftD-2csuA:
undetectable
4aftE-2csuA:
undetectable		 4aftD-2csuA:
18.28
4aftE-2csuA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 GLU A  86
ASP A  79
GLN A  83
ILE A 116
 None
 1.10A 4ii8A-2csuA:
undetectable		 4ii8A-2csuA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ARG A 123
GLY A 131
ASP A 187
ILE A 132
ILE A  94
 None
 1.01A 4q5mA-2csuA:
undetectable		 4q5mA-2csuA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 PHE A 190
ILE A 210
GLY A 216
PHE A 219
 None
 0.89A 5h3aA-2csuA:
undetectable		 5h3aA-2csuA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 VAL A  89
ILE A  14
CYH A 129
ASN A 140
 None
 0.96A 5hieC-2csuA:
undetectable		 5hieC-2csuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ASP A  66
TYR A  34
GLY A  37
TYR A  40
 None
 1.04A 5hwaA-2csuA:
undetectable		 5hwaA-2csuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ASP A 187
HIS A 118
ILE A 116
TYR A   4
 None
 1.25A 5ih0A-2csuA:
undetectable		 5ih0A-2csuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LYS A  29
LEU A 139
ILE A  69
 None
 0.55A 5kc0A-2csuA:
1.5		 5kc0A-2csuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LYS A  29
LEU A 139
ILE A  69
 None
 0.65A 5kc4A-2csuA:
undetectable		 5kc4A-2csuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 179
ILE A 132
ALA A 186
VAL A 182
ILE A 125
 None
 1.44A 5mlmA-2csuA:
3.0		 5mlmA-2csuA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 MET A 347
ASN A 343
VAL A 341
LEU A 335
 None
 0.96A 5xdhA-2csuA:
undetectable
5xdhC-2csuA:
undetectable		 5xdhA-2csuA:
11.24
5xdhC-2csuA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLU A 424
ALA A 390
ALA A 408
ALA A 374
PHE A 410
 None
 0.96A 5zw4A-2csuA:
6.4		 5zw4A-2csuA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ALA A 207
ILE A 174
VAL A 152
PRO A 429
 None
 0.92A 6cduF-2csuA:
undetectable
6cduJ-2csuA:
undetectable		 6cduF-2csuA:
22.27
6cduJ-2csuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2csu 457AA LONG
HYPOTHETICAL PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 440
VAL A 437
ILE A 298
ALA A 297
LEU A 313
 None
 1.34A 6h1lA-2csuA:
undetectable		 6h1lA-2csuA:
23.08