SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2csw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 11 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.49A 3m8pA-2cswA:
0.0
3m8pB-2cswA:
undetectable		 3m8pA-2cswA:
13.62
3m8pB-2cswA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 12 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.43A 5cymA-2cswA:
undetectable		 5cymA-2cswA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 12 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.44A 5cyqA-2cswA:
undetectable		 5cyqA-2cswA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 9 VAL A  46
LEU A 108
LEU A  50
GLN A  49
THR A  39
 None
 1.27A 6czmA-2cswA:
undetectable
6czmB-2cswA:
undetectable		 6czmA-2cswA:
16.48
6czmB-2cswA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 9 VAL A  46
LEU A 108
LEU A  50
GLN A  49
THR A  39
 None
 1.32A 6czmB-2cswA:
undetectable
6czmC-2cswA:
undetectable		 6czmB-2cswA:
16.48
6czmC-2cswA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 8 LEU A  50
GLN A  49
THR A  39
VAL A  46
LEU A 108
 None
 1.28A 6czmD-2cswA:
undetectable
6czmF-2cswA:
undetectable		 6czmD-2cswA:
16.48
6czmF-2cswA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2csw UBIQUITIN LIGASE
PROTEIN RNF8
(Homo
sapiens) 		5 / 12 LEU A 108
VAL A  46
VAL A  65
TYR A  48
LEU A  50
 None
 1.42A 6eliA-2cswA:
undetectable		 6eliA-2cswA:
18.62