SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ct6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HVY_C_D16C416_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 11	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.23A	1hvyC-2ct6A: undetectable	1hvyC-2ct6A: 14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I00_B_D16B409_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 9	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.27A	1i00B-2ct6A: undetectable	1i00B-2ct6A: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	4 / 8	ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	0.95A	2tsrB-2ct6A: undetectable	2tsrB-2ct6A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_C_D16C509_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 10	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.29A	2tsrC-2ct6A: undetectable	2tsrC-2ct6A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_D_D16D609_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 9	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.24A	2tsrD-2ct6A: undetectable	2tsrD-2ct6A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BRF_A_SORA2_0 (LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	3 / 3	LYS A 65 LYS A 58 VAL A 60	None	1.09A	3brfA-2ct6A: undetectable	3brfA-2ct6A: 11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I45_A_NIOA500_1 (TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL PROTEIN)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	4 / 8	PHE A 89 LEU A 102 PHE A 33 LEU A 34	None	1.02A	3i45A-2ct6A: undetectable	3i45A-2ct6A: 15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_A_D16A402_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 12	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.24A	4eb4A-2ct6A: undetectable	4eb4A-2ct6A: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_B_D16B402_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 12	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.25A	4eb4B-2ct6A: undetectable	4eb4B-2ct6A: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_C_D16C402_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 9	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.27A	4eb4C-2ct6A: undetectable	4eb4C-2ct6A: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB4_D_D16D402_1 (THYMIDYLATE SYNTHASE)	2ct6	SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 (Homo sapiens)	5 / 10	PHE A 89 ILE A 76 LEU A 104 GLY A 103 PHE A 101	None	1.26A	4eb4D-2ct6A: undetectable	4eb4D-2ct6A: 14.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HVY_C_D16C416_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.23A","1hvyC-2ct6A:undetectable","1hvyC-2ct6A:14.58"],["1I00_B_D16B409_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.27A","1i00B-2ct6A:undetectable","1i00B-2ct6A:15.38"],["2TSR_B_D16B409_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",4,"ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","0.95A","2tsrB-2ct6A:undetectable","2tsrB-2ct6A:16.21"],["2TSR_C_D16C509_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.29A","2tsrC-2ct6A:undetectable","2tsrC-2ct6A:16.21"],["2TSR_D_D16D609_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.24A","2tsrD-2ct6A:undetectable","2tsrD-2ct6A:16.21"],["3BRF_A_SORA2_0","LIN-12 AND GLP-1 PHENOTYPE PROTEIN 1, ISOFORM A","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",3,"LYS A  65;LYS A  58;VAL A  60","None","1.09A","3brfA-2ct6A:undetectable","3brfA-2ct6A:11.56"],["3I45_A_NIOA500_1","TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL PROTEIN","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",4,"PHE A  89;LEU A 102;PHE A  33;LEU A  34","None","1.02A","3i45A-2ct6A:undetectable","3i45A-2ct6A:15.54"],["4EB4_A_D16A402_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.24A","4eb4A-2ct6A:undetectable","4eb4A-2ct6A:14.09"],["4EB4_B_D16B402_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.25A","4eb4B-2ct6A:undetectable","4eb4B-2ct6A:14.09"],["4EB4_C_D16C402_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.27A","4eb4C-2ct6A:undetectable","4eb4C-2ct6A:14.09"],["4EB4_D_D16D402_1","THYMIDYLATE SYNTHASE","2ct6","SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2","Homo sapiens",5,"PHE A  89;ILE A  76;LEU A 104;GLY A 103;PHE A 101","None","1.26A","4eb4D-2ct6A:undetectable","4eb4D-2ct6A:14.09"]]