SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ct8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 1dz4A-2ct8A:
undetectable		 1dz4A-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.11A 1dz4B-2ct8A:
undetectable		 1dz4B-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.09A 1dz6B-2ct8A:
undetectable		 1dz6B-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 1dz9A-2ct8A:
undetectable		 1dz9A-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 HIS A  21
GLY A  23
GLY A 257
ASP A 259
HIS A 286
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.4A)
 0.79A 1ffyA-2ct8A:
25.0		 1ffyA-2ct8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 HIS A  24
GLY A  23
GLY A 257
ASP A 259
HIS A 286
 MSP  A 501 (-4.2A)
MSP  A 501 (-3.6A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.4A)
 1.19A 1ffyA-2ct8A:
25.0		 1ffyA-2ct8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.12A 1o76B-2ct8A:
undetectable		 1o76B-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		7 / 11 HIS A  21
GLY A  23
HIS A  24
GLY A 257
ASP A 259
ILE A 260
HIS A 286
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.1A)
MSP  A 501 (-4.4A)
 0.55A 1pg2A-2ct8A:
40.6		 1pg2A-2ct8A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		6 / 12 HIS A  21
GLY A  23
HIS A  24
GLY A 257
ASP A 259
HIS A 286
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.4A)
 0.79A 1qu2A-2ct8A:
25.0		 1qu2A-2ct8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 HIS A  21
GLY A  23
HIS A  24
ASP A 259
HIS A 286
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.4A)
 0.94A 1qu3A-2ct8A:
29.4		 1qu3A-2ct8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 4 LEU A 475
ILE A 402
ARG A 324
TYR A  37
 None
 1.49A 1rk3A-2ct8A:
0.0		 1rk3A-2ct8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 1uyuA-2ct8A:
undetectable		 1uyuA-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.10A 1uyuB-2ct8A:
undetectable		 1uyuB-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 4 PHE A 105
ASP A 232
PHE A 231
VAL A 109
 None
 1.33A 1w0fA-2ct8A:
0.0		 1w0fA-2ct8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.04A 1yrdA-2ct8A:
undetectable		 1yrdA-2ct8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 ALA A 462
ASN A 457
ILE A 405
ILE A 402
THR A 455
 None
 1.24A 2bjfA-2ct8A:
undetectable		 2bjfA-2ct8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 ASP A 375
TYR A 478
TYR A 411
TYR A 415
 None
 1.36A 2ha2B-2ct8A:
undetectable		 2ha2B-2ct8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 LEU A 275
PHE A 110
PHE A 235
PHE A 164
 None
 0.97A 2opxA-2ct8A:
2.5		 2opxA-2ct8A:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		8 / 11 HIS A  21
GLY A  23
HIS A  24
GLY A 257
ASP A 259
ILE A 260
HIS A 286
TRP A 288
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.1A)
MSP  A 501 (-4.4A)
MSP  A 501 (-3.5A)
 0.48A 2x1lA-2ct8A:
44.1		 2x1lA-2ct8A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		8 / 12 HIS A  21
GLY A  23
HIS A  24
GLY A 257
ASP A 259
ILE A 260
HIS A 286
TRP A 288
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.1A)
MSP  A 501 (-4.4A)
MSP  A 501 (-3.5A)
 0.46A 2x1lB-2ct8A:
47.1		 2x1lB-2ct8A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		8 / 11 HIS A  21
GLY A  23
HIS A  24
GLY A 257
ASP A 259
ILE A 260
HIS A 286
TRP A 288
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.1A)
MSP  A 501 (-4.4A)
MSP  A 501 (-3.5A)
 0.46A 2x1lC-2ct8A:
46.8		 2x1lC-2ct8A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 11 HIS A  24
GLY A  23
GLY A 257
ASP A 259
HIS A 286
 MSP  A 501 (-4.2A)
MSP  A 501 (-3.6A)
MSP  A 501 (-2.9A)
MSP  A 501 (-3.0A)
MSP  A 501 (-4.4A)
 1.08A 2x1lC-2ct8A:
46.8		 2x1lC-2ct8A:
44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 2zawA-2ct8A:
undetectable		 2zawA-2ct8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.07A 2zaxA-2ct8A:
undetectable		 2zaxA-2ct8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 5 LEU A 475
ILE A 402
ARG A 324
TYR A  37
 None
 1.43A 2zlcA-2ct8A:
undetectable		 2zlcA-2ct8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 9 ASP A  52
GLY A 216
PRO A  69
ALA A  62
ILE A  58
 MSP  A 501 (-3.9A)
None
None
None
None
 1.08A 3ektB-2ct8A:
undetectable		 3ektB-2ct8A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 3fwgA-2ct8A:
undetectable		 3fwgA-2ct8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 4 LEU A 255
ILE A 402
TYR A  37
TYR A  26
 None
 1.39A 3vt7A-2ct8A:
undetectable		 3vt7A-2ct8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 3wrhE-2ct8A:
undetectable		 3wrhE-2ct8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.10A 3wrjE-2ct8A:
undetectable		 3wrjE-2ct8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 TYR A 483
ILE A 386
GLU A 390
VAL A 446
HIS A 449
 None
 1.27A 4azsA-2ct8A:
2.1		 4azsA-2ct8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.09A 4ek1A-2ct8A:
undetectable		 4ek1A-2ct8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 4g3rA-2ct8A:
undetectable		 4g3rA-2ct8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.10A 4g3rB-2ct8A:
undetectable		 4g3rB-2ct8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 4kkyX-2ct8A:
undetectable		 4kkyX-2ct8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.05A 4l4bA-2ct8A:
undetectable		 4l4bA-2ct8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.08A 4l4cA-2ct8A:
undetectable		 4l4cA-2ct8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.09A 4l4dA-2ct8A:
undetectable		 4l4dA-2ct8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.12A 4l4eA-2ct8A:
undetectable		 4l4eA-2ct8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.11A 4l4fA-2ct8A:
0.0		 4l4fA-2ct8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 TYR A  26
LEU A 253
PHE A   7
PHE A 328
THR A  28
 None
 1.34A 4ze1A-2ct8A:
undetectable		 4ze1A-2ct8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 ASN A 236
LEU A 272
PHE A 263
 MSP  A 501 (-4.7A)
None
None
 0.82A 5dsgA-2ct8A:
undetectable		 5dsgA-2ct8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 HIS A  21
GLY A  23
HIS A  24
VAL A 229
ASP A 259
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
None
MSP  A 501 (-3.0A)
 1.01A 5hg0B-2ct8A:
6.4		 5hg0B-2ct8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 12 HIS A  21
GLY A  23
HIS A  24
VAL A 229
GLY A 257
 MSP  A 501 (-4.6A)
MSP  A 501 (-3.6A)
MSP  A 501 (-4.2A)
None
MSP  A 501 (-2.9A)
 0.89A 5hg0B-2ct8A:
6.4		 5hg0B-2ct8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 THR A  97
ASP A  52
ASP A 232
GLY A  55
 None
MSP  A 501 (-3.9A)
None
None
 0.89A 5hwaA-2ct8A:
undetectable		 5hwaA-2ct8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		5 / 10 VAL A 283
THR A 265
LEU A 234
GLY A 257
ALA A 285
 None
None
MSP  A 501 ( 4.6A)
MSP  A 501 (-2.9A)
None
 0.96A 5mxbA-2ct8A:
undetectable		 5mxbA-2ct8A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 7 GLY A  50
LEU A 255
THR A  28
ALA A  31
 None
 0.71A 5o96C-2ct8A:
undetectable		 5o96C-2ct8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 6 ARG A  79
PHE A  86
ILE A  29
THR A  28
 None
 0.92A 5vceA-2ct8A:
undetectable		 5vceA-2ct8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		3 / 3 ALA A 338
VAL A 309
TYR A 313
 None
 0.45A 5zmqH-2ct8A:
undetectable		 5zmqH-2ct8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2ct8 METHIONYL-TRNA
SYNTHETASE
(Aquifex
aeolicus) 		4 / 8 PHE A   7
TYR A  38
VAL A 396
ASP A 252
 None
 1.05A 6cp4A-2ct8A:
undetectable		 6cp4A-2ct8A:
20.49