SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ctz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 LEU A 245
VAL A 258
PHE A  48
LEU A  45
TYR A 242
 None
 1.50A 1klmA-2ctzA:
undetectable		 1klmA-2ctzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 235
LEU A 234
LEU A 247
ALA A 255
ASP A 263
 None
 1.10A 1tw4A-2ctzA:
undetectable		 1tw4A-2ctzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 235
LEU A 234
LEU A 247
ILE A 257
ASP A 263
 None
 1.01A 1tw4A-2ctzA:
undetectable		 1tw4A-2ctzA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 ASP A 221
GLY A 252
ALA A 260
ILE A 257
 None
 0.93A 2aofA-2ctzA:
undetectable		 2aofA-2ctzA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  90
VAL A 175
ALA A 176
LEU A 177
VAL A 101
 None
 1.04A 2c12C-2ctzA:
undetectable		 2c12C-2ctzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 PHE A 183
VAL A 367
TRP A 207
 None
 0.88A 2cc8A-2ctzA:
undetectable		 2cc8A-2ctzA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 PHE A 183
VAL A 367
TRP A 207
 None
 0.87A 2ccbA-2ctzA:
undetectable		 2ccbA-2ctzA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 266
GLY A 241
PRO A 240
 None
 0.77A 2hreD-2ctzA:
undetectable		 2hreD-2ctzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  70
GLY A 186
VAL A 280
ARG A 290
ALA A  76
 None
 1.04A 2oz7A-2ctzA:
undetectable		 2oz7A-2ctzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 PHE A 332
ILE A 178
ILE A 219
GLY A 184
 None
 0.85A 2v0mB-2ctzA:
undetectable		 2v0mB-2ctzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 PHE A 183
VAL A 367
TRP A 207
 None
 0.88A 2vx9A-2ctzA:
undetectable		 2vx9A-2ctzA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ARG A 327
ILE A 160
ILE A 178
ALA A 198
PHE A 137
 None
 1.20A 3axtA-2ctzA:
3.7		 3axtA-2ctzA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 THR A 103
THR A 128
ILE A 153
ILE A 160
LEU A 106
 None
 1.15A 3gwxA-2ctzA:
undetectable		 3gwxA-2ctzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 199
LEU A 235
ILE A 257
ALA A 260
LEU A  88
 None
 1.03A 3n8zB-2ctzA:
undetectable		 3n8zB-2ctzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 LEU A  90
THR A  91
VAL A 116
THR A 117
PHE A 127
 None
 1.43A 3tbgA-2ctzA:
undetectable		 3tbgA-2ctzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 10 LEU A  90
THR A  91
VAL A 116
THR A 117
PHE A 127
 None
 1.38A 3tbgC-2ctzA:
undetectable		 3tbgC-2ctzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 HIS A 202
LEU A  67
GLY A  82
ALA A  85
 None
None
PLP  A 600 (-3.2A)
None
 1.00A 3tehB-2ctzA:
2.0		 3tehB-2ctzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 ILE A  55
ARG A 261
LEU A 265
GLY A 273
 None
 0.89A 3w1wA-2ctzA:
2.6		 3w1wA-2ctzA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 214
ILE A 257
VAL A  60
LEU A  63
VAL A 280
 None
 0.92A 3w68D-2ctzA:
undetectable		 3w68D-2ctzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 ASN A 159
GLU A 131
GLU A 132
ARG A 133
 None
 0.89A 4mj8B-2ctzA:
undetectable
4mj8C-2ctzA:
undetectable		 4mj8B-2ctzA:
17.03
4mj8C-2ctzA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 PHE A 332
ILE A 160
ARG A 327
VAL A 179
 None
 1.29A 4mk4B-2ctzA:
2.9		 4mk4B-2ctzA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 VAL A 208
LEU A 204
VAL A 280
 None
 0.61A 4wq4A-2ctzA:
undetectable		 4wq4A-2ctzA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 299
ALA A 302
LEU A 340
HIS A 325
LEU A 306
 None
 1.17A 4zn7A-2ctzA:
undetectable		 4zn7A-2ctzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 LYS A 352
GLU A 349
GLY A 347
GLY A 346
 None
 0.91A 5a06D-2ctzA:
undetectable		 5a06D-2ctzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 MET A 185
HIS A 294
GLY A 209
 None
 0.86A 5gwzB-2ctzA:
undetectable		 5gwzB-2ctzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 ASP A 263
GLY A 264
ASP A 267
LYS A 259
 None
 1.42A 5hp1C-2ctzA:
2.1		 5hp1C-2ctzA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 ILE A 361
ILE A 375
HIS A 376
VAL A 400
 None
 0.87A 5jmnA-2ctzA:
undetectable		 5jmnA-2ctzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 8 ALA A 374
LEU A 416
LEU A 412
LEU A 340
LEU A 305
 None
 1.36A 5jqbA-2ctzA:
undetectable
5jqbB-2ctzA:
undetectable		 5jqbA-2ctzA:
19.82
5jqbB-2ctzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 187
VAL A 220
ALA A 194
LEU A 193
ALA A 197
 None
 0.88A 5kpcA-2ctzA:
undetectable		 5kpcA-2ctzA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  90
THR A 201
THR A 117
GLY A  82
HIS A  83
 None
None
None
PLP  A 600 (-3.2A)
PLP  A 600 (-3.9A)
 1.31A 5utuF-2ctzA:
undetectable		 5utuF-2ctzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  67
VAL A 179
THR A  79
LEU A 272
ALA A 216
 None
 1.06A 6djzC-2ctzA:
undetectable		 6djzC-2ctzA:
23.61