SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 247
ASN A 275
GLY A 296
CYH A 301
GLY A 383
 None
XMP  A1001 ( 4.4A)
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.1A)
 1.17A 1jr1A-2cu0A:
51.0		 1jr1A-2cu0A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		6 / 11 ASP A 247
ASN A 275
GLY A 296
CYH A 301
THR A 303
GLY A 385
 None
XMP  A1001 ( 4.4A)
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
XMP  A1001 (-3.1A)
 0.48A 1jr1A-2cu0A:
51.0		 1jr1A-2cu0A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 ASP A 247
ASN A 275
GLY A 296
THR A 303
GLY A 385
 None
XMP  A1001 ( 4.4A)
None
XMP  A1001 (-3.7A)
XMP  A1001 (-3.1A)
 0.43A 1jr1B-2cu0A:
51.0		 1jr1B-2cu0A:
33.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		6 / 8 ASP A 247
ASN A 275
ILE A 295
GLY A 296
CYH A 301
GLY A 385
 None
XMP  A1001 ( 4.4A)
None
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.1A)
 0.45A 1me7A-2cu0A:
48.0		 1me7A-2cu0A:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 247
ASN A 275
ILE A 295
GLY A 296
GLU A 412
 None
XMP  A1001 ( 4.4A)
None
None
None
 1.13A 1mehA-2cu0A:
46.1		 1mehA-2cu0A:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 247
ASN A 275
ILE A 295
GLY A 296
GLY A 385
 None
XMP  A1001 ( 4.4A)
None
None
XMP  A1001 (-3.1A)
 0.42A 1mehA-2cu0A:
46.1		 1mehA-2cu0A:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 ASP A 247
ASN A 275
ILE A 295
GLY A 385
 None
XMP  A1001 ( 4.4A)
None
XMP  A1001 (-3.1A)
 0.44A 1meiA-2cu0A:
47.5		 1meiA-2cu0A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 TYR A 381
GLY A 335
GLY A 357
LEU A 356
SER A 299
 XMP  A1001 (-4.5A)
XMP  A1001 (-3.4A)
XMP  A1001 (-3.3A)
None
XMP  A1001 (-2.7A)
 1.23A 1qzzA-2cu0A:
undetectable		 1qzzA-2cu0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  30
GLU A 449
LEU A  22
 None
 0.60A 1v8bA-2cu0A:
undetectable		 1v8bA-2cu0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A  30
GLU A 449
LEU A  22
 None
 0.57A 1v8bB-2cu0A:
undetectable		 1v8bB-2cu0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 268
ILE A 230
VAL A 273
 None
 0.68A 2avvD-2cu0A:
undetectable		 2avvD-2cu0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 356
ILE A 337
GLY A 336
GLY A 298
SER A  52
 None
None
XMP  A1001 (-3.6A)
XMP  A1001 (-3.5A)
None
 0.95A 2qmmA-2cu0A:
undetectable		 2qmmA-2cu0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 356
ILE A 337
GLY A 336
GLY A 298
SER A  52
 None
None
XMP  A1001 (-3.6A)
XMP  A1001 (-3.5A)
None
 0.95A 2qmmA-2cu0A:
undetectable
2qmmB-2cu0A:
undetectable		 2qmmA-2cu0A:
17.18
2qmmB-2cu0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 275
VAL A  75
ALA A 224
VAL A  58
THR A  59
 XMP  A1001 ( 4.4A)
None
None
None
None
 1.10A 3czhA-2cu0A:
undetectable		 3czhA-2cu0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ALA A  66
ARG A  69
LYS A 207
 None
 0.87A 3kp3B-2cu0A:
undetectable		 3kp3B-2cu0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A 429
VAL A  36
ILE A  50
ARG A 213
 None
 1.22A 3ms9B-2cu0A:
undetectable		 3ms9B-2cu0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.32A 3w9tA-2cu0A:
undetectable		 3w9tA-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.31A 3w9tB-2cu0A:
undetectable		 3w9tB-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.32A 3w9tC-2cu0A:
undetectable		 3w9tC-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.32A 3w9tD-2cu0A:
undetectable		 3w9tD-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 342
GLY A 336
TYR A 339
ASP A  18
 None
XMP  A1001 (-3.6A)
None
None
 1.19A 3w9tD-2cu0A:
undetectable		 3w9tD-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.32A 3w9tE-2cu0A:
undetectable		 3w9tE-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.32A 3w9tF-2cu0A:
undetectable		 3w9tF-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 214
 None
 1.31A 3w9tG-2cu0A:
undetectable		 3w9tG-2cu0A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  40
ASP A 352
ILE A 332
GLY A 274
 None
 0.83A 4acaC-2cu0A:
undetectable		 4acaC-2cu0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  40
ASP A 352
ILE A 332
GLY A 274
 None
 0.72A 4acbC-2cu0A:
undetectable		 4acbC-2cu0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 SER A 299
TYR A 381
GLY A 335
PRO A 297
 XMP  A1001 (-2.7A)
XMP  A1001 (-4.5A)
XMP  A1001 (-3.4A)
None
 1.48A 4e3aA-2cu0A:
1.8		 4e3aA-2cu0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 4 SER A 299
TYR A 381
GLY A 336
PRO A 297
 XMP  A1001 (-2.7A)
XMP  A1001 (-4.5A)
XMP  A1001 (-3.6A)
None
 1.31A 4e3aA-2cu0A:
1.8		 4e3aA-2cu0A:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		6 / 8 ASP A 247
ASN A 275
CYH A 301
THR A 303
MET A 384
GLY A 385
 None
XMP  A1001 ( 4.4A)
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
None
XMP  A1001 (-3.1A)
 0.66A 4fo4A-2cu0A:
51.4		 4fo4A-2cu0A:
41.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		6 / 8 ASN A 275
GLY A 296
CYH A 301
THR A 303
MET A 384
GLY A 385
 XMP  A1001 ( 4.4A)
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
None
XMP  A1001 (-3.1A)
 0.32A 4fo4B-2cu0A:
49.1		 4fo4B-2cu0A:
41.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		6 / 9 ASN A 275
ILE A 295
GLY A 296
CYH A 301
THR A 303
ASP A 334
 XMP  A1001 ( 4.4A)
None
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
XMP  A1001 (-2.4A)
 0.31A 4fxsA-2cu0A:
54.0		 4fxsA-2cu0A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 9 ASP A 247
ILE A 295
GLY A 296
CYH A 301
THR A 303
 None
None
None
XMP  A1001 (-2.6A)
XMP  A1001 (-3.7A)
 0.78A 4fxsA-2cu0A:
54.0		 4fxsA-2cu0A:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 ILE A 337
VAL A 354
PRO A  49
 None
 0.50A 5uunA-2cu0A:
undetectable		 5uunA-2cu0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A 342
ALA A 351
GLY A 335
ARG A 338
VAL A 293
 None
None
XMP  A1001 (-3.4A)
None
None
 1.30A 6clxA-2cu0A:
undetectable		 6clxA-2cu0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 222
LEU A  51
VAL A  36
THR A  41
ALA A 290
 None
 1.15A 6djzC-2cu0A:
undetectable		 6djzC-2cu0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 219
VAL A 225
MET A  67
GLY A  71
 None
 0.97A 6hd4B-2cu0A:
undetectable		 6hd4B-2cu0A:
11.26