SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2
(Homo
sapiens) 		4 / 5 LEU A  71
VAL A  68
LEU A  64
GLN A  61
 None
 0.89A 1fbmE-2cu1A:
undetectable		 1fbmE-2cu1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2
(Homo
sapiens) 		5 / 11 LEU A  33
VAL A  28
TYR A  49
LEU A  71
HIS A  48
 None
 1.39A 1qabE-2cu1A:
0.0		 1qabE-2cu1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2
(Homo
sapiens) 		3 / 3 ASP A  63
VAL A  68
PRO A  27
 None
 0.76A 2avvA-2cu1A:
undetectable		 2avvA-2cu1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2
(Homo
sapiens) 		5 / 10 VAL A  11
LEU A  64
VAL A  68
VAL A  28
LEU A  33
 None
 1.07A 3gwxA-2cu1A:
undetectable		 3gwxA-2cu1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2
(Homo
sapiens) 		5 / 8 LEU A  58
VAL A  68
LEU A  80
VAL A  28
LEU A  33
 None
 1.12A 3kp6A-2cu1A:
undetectable
3kp6B-2cu1A:
undetectable		 3kp6A-2cu1A:
24.07
3kp6B-2cu1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2
(Homo
sapiens) 		4 / 6 ILE A  86
MET A  45
ASN A  87
ASP A  46
 None
 1.47A 6dhbA-2cu1A:
undetectable		 6dhbA-2cu1A:
18.80