SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 205
LEU A 228
TYR A 225
LEU A 215
 None
 1.13A 1hk2A-2cu2A:
undetectable		 1hk2A-2cu2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 138
GLY A 187
GLY A 188
TYR A 183
GLY A 163
 None
 0.96A 1n2xB-2cu2A:
undetectable		 1n2xB-2cu2A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 SER A  20
PHE A  32
LEU A 262
VAL A 290
ALA A 309
 None
 1.43A 1q23D-2cu2A:
undetectable
1q23E-2cu2A:
undetectable		 1q23D-2cu2A:
19.66
1q23E-2cu2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A 166
ASN A 186
PHE A 190
SER A 232
 None
 1.38A 1rqpB-2cu2A:
undetectable		 1rqpB-2cu2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 8 ARG A 245
HIS A 204
ARG A 243
VAL A 134
 None
 1.33A 1u1jA-2cu2A:
undetectable		 1u1jA-2cu2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A  56
ILE A  73
GLU A 116
GLU A  43
LEU A  45
 None
 1.12A 1wopA-2cu2A:
undetectable		 1wopA-2cu2A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 215
LEU A  89
GLY A 227
ARG A 214
ALA A 226
 None
 1.05A 2bm9C-2cu2A:
undetectable		 2bm9C-2cu2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 215
LEU A  89
GLY A 227
ARG A 214
ALA A 226
 None
 1.01A 2bm9D-2cu2A:
undetectable		 2bm9D-2cu2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 7 GLU A 130
PRO A 194
MET A 197
GLY A 132
 None
 1.23A 2hs1B-2cu2A:
undetectable		 2hs1B-2cu2A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  38
LEU A  42
GLU A  63
ARG A  67
 None
 1.08A 2jn3A-2cu2A:
undetectable		 2jn3A-2cu2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A 166
ASN A 186
PHE A 190
SER A 232
 None
 1.40A 2v7uB-2cu2A:
undetectable		 2v7uB-2cu2A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 188
ILE A 233
LEU A 137
ASP A 255
ARG A  44
 None
 0.98A 2yqzA-2cu2A:
undetectable		 2yqzA-2cu2A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 7 TRP A 185
GLY A 113
ASP A 254
ARG A 264
 None
 1.31A 3arrA-2cu2A:
undetectable		 3arrA-2cu2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 6 ARG A  15
ASP A 109
LYS A  26
ARG A 264
 SO4  A1001 (-3.8A)
None
None
None
 1.44A 3jqzA-2cu2A:
0.1		 3jqzA-2cu2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 205
VAL A 237
MET A 238
PHE A 192
 None
 1.05A 3soaA-2cu2A:
undetectable		 3soaA-2cu2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 6 GLU A 263
ASP A 254
ASP A 321
ASN A 258
 None
 1.23A 3vywA-2cu2A:
undetectable		 3vywA-2cu2A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 5 GLU A 263
ASP A 254
ASP A 321
ASN A 258
 None
 1.21A 3vywD-2cu2A:
undetectable		 3vywD-2cu2A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 279
GLY A 277
THR A  36
LEU A  19
VAL A 311
 None
 0.96A 4o3fA-2cu2A:
undetectable		 4o3fA-2cu2A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A  89
LEU A  90
LEU A 215
GLU A 223
LEU A 221
 None
 1.01A 4wg0H-2cu2A:
undetectable
4wg0I-2cu2A:
undetectable
4wg0J-2cu2A:
undetectable		 4wg0H-2cu2A:
3.42
4wg0I-2cu2A:
3.42
4wg0J-2cu2A:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLU A 223
LEU A 221
LEU A 215
LEU A  89
LEU A  90
 None
 0.97A 4wg0K-2cu2A:
undetectable
4wg0L-2cu2A:
undetectable
4wg0M-2cu2A:
undetectable		 4wg0K-2cu2A:
3.42
4wg0L-2cu2A:
3.42
4wg0M-2cu2A:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		4 / 5 GLY A 163
ARG A 162
GLY A 154
GLU A 157
 None
 1.19A 4z2eB-2cu2A:
undetectable
4z2eC-2cu2A:
undetectable		 4z2eB-2cu2A:
21.24
4z2eC-2cu2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLU A 263
GLY A 257
ASN A 258
TYR A 148
TRP A 253
 None
 1.27A 5ayfA-2cu2A:
undetectable		 5ayfA-2cu2A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 103
LEU A  90
GLY A  91
LEU A   6
ALA A  57
 None
 1.09A 5dqfA-2cu2A:
undetectable		 5dqfA-2cu2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 MET A 125
ALA A 121
GLU A 116
LEU A  48
VAL A 112
 None
 1.26A 5vlmB-2cu2A:
undetectable		 5vlmB-2cu2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 224
LEU A 221
VAL A  92
ALA A  93
LEU A 215
 None
 1.18A 6ajiA-2cu2A:
undetectable		 6ajiA-2cu2A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE
(Thermus
thermophilus) 		5 / 9 ILE A 233
ALA A  85
GLY A  86
LEU A  90
GLY A  10
 None
 1.17A 6nm4B-2cu2A:
undetectable		 6nm4B-2cu2A:
17.89