SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.97A 1cqeA-2cu5A:
undetectable		 1cqeA-2cu5A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.98A 1cqeB-2cu5A:
undetectable		 1cqeB-2cu5A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		3 / 3 TRP A 125
VAL A  38
PRO A  39
 None
 0.85A 1rg1A-2cu5A:
undetectable		 1rg1A-2cu5A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		3 / 3 TRP A 125
VAL A  38
PRO A  39
 None
 0.84A 1rh0A-2cu5A:
undetectable		 1rh0A-2cu5A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 LEU A  60
LEU A  63
LEU A  66
ALA A  67
LEU A  85
 None
 0.95A 1s9pC-2cu5A:
undetectable		 1s9pC-2cu5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.85A 2aylA-2cu5A:
undetectable		 2aylA-2cu5A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.95A 2aylB-2cu5A:
undetectable		 2aylB-2cu5A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		4 / 6 VAL A  38
LEU A 113
GLU A 115
CYH A  43
 None
 1.13A 3b6rB-2cu5A:
undetectable		 3b6rB-2cu5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 9 VAL A 111
ILE A  19
ALA A  25
VAL A 126
VAL A 124
 None
 1.22A 3me6C-2cu5A:
undetectable		 3me6C-2cu5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 9 VAL A 111
ILE A  19
ALA A  25
VAL A 126
VAL A 124
 None
 1.26A 3me6D-2cu5A:
undetectable		 3me6D-2cu5A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		6 / 12 VAL A 111
VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 1.49A 3n8wA-2cu5A:
undetectable		 3n8wA-2cu5A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.90A 3nt1A-2cu5A:
undetectable		 3nt1A-2cu5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.91A 3nt1B-2cu5A:
undetectable		 3nt1B-2cu5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		3 / 3 ARG A 122
LEU A 113
THR A  90
 None
 0.72A 3oxcA-2cu5A:
undetectable		 3oxcA-2cu5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		6 / 12 VAL A 111
VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 1.44A 3pghC-2cu5A:
undetectable		 3pghC-2cu5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 1.03A 3pghD-2cu5A:
undetectable		 3pghD-2cu5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		3 / 3 HIS A  40
ARG A 122
GLU A 123
 None
 0.88A 3qf1A-2cu5A:
undetectable		 3qf1A-2cu5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 9 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.97A 4rs0A-2cu5A:
undetectable		 4rs0A-2cu5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.98A 5ikrB-2cu5A:
undetectable		 5ikrB-2cu5A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.91A 5jvzA-2cu5A:
undetectable		 5jvzA-2cu5A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		5 / 12 VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 0.93A 5jvzB-2cu5A:
undetectable		 5jvzB-2cu5A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486
(Thermus
thermophilus) 		3 / 3 THR A  11
GLU A 115
HIS A  40
 None
 0.91A 5xiqB-2cu5A:
undetectable		 5xiqB-2cu5A:
14.26