SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 THR A 106
LEU A 110
VAL A 113
 None
 0.60A 1mz9E-2cukA:
undetectable		 1mz9E-2cukA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 VAL A 273
LEU A 105
THR A 102
THR A 275
ILE A 274
 None
 1.22A 1pkvA-2cukA:
undetectable
1pkvB-2cukA:
undetectable		 1pkvA-2cukA:
13.82
1pkvB-2cukA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 5 LEU A 252
GLY A 263
ALA A 272
ILE A 274
 None
 0.86A 2aohB-2cukA:
undetectable		 2aohB-2cukA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 225
VAL A 197
VAL A 150
GLY A 231
LEU A  98
 None
 1.17A 2cbrA-2cukA:
undetectable		 2cbrA-2cukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.54A 2po5B-2cukA:
2.3		 2po5B-2cukA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.54A 2po7B-2cukA:
4.2		 2po7B-2cukA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 THR A 275
ASN A 271
VAL A 113
GLY A 251
ALA A 112
 None
 1.26A 2x2iA-2cukA:
undetectable		 2x2iA-2cukA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 THR A 275
ASN A 271
VAL A 113
GLY A 251
ALA A 112
 None
 1.28A 2x2iC-2cukA:
undetectable		 2x2iC-2cukA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 LEU A 266
PRO A 265
LEU A 269
 None
 0.49A 3hcrA-2cukA:
4.9		 3hcrA-2cukA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 7 PRO A  49
VAL A  41
LEU A  66
ILE A  55
 None
 0.95A 3u5kB-2cukA:
undetectable		 3u5kB-2cukA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ARG A 125
LEU A 137
VAL A 118
GLY A 120
ALA A 121
 None
 1.05A 4coxA-2cukA:
undetectable		 4coxA-2cukA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ARG A 125
LEU A 137
VAL A 118
GLY A 120
ALA A 121
 None
 1.05A 4coxB-2cukA:
undetectable		 4coxB-2cukA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ARG A 125
LEU A 137
VAL A 118
GLY A 120
ALA A 121
 None
 1.05A 4coxD-2cukA:
undetectable		 4coxD-2cukA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 252
LEU A 226
LEU A 199
ILE A 155
LEU A 105
 None
 1.32A 4j24C-2cukA:
undetectable		 4j24C-2cukA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 4 ASP A  53
LEU A  37
ARG A   2
THR A  50
 None
 1.30A 4kjjA-2cukA:
2.3		 4kjjA-2cukA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 4 ASP A  53
LEU A  37
ARG A   2
THR A  50
 None
 1.35A 4kjkA-2cukA:
undetectable		 4kjkA-2cukA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 5 ASP A  53
LEU A  37
ARG A   2
THR A  50
 None
 1.39A 4p3qA-2cukA:
undetectable		 4p3qA-2cukA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 6 THR A 204
GLU A 206
THR A 207
THR A 176
 None
 1.02A 4pgfA-2cukA:
12.2		 4pgfA-2cukA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A 238
THR A 201
LEU A 225
LEU A 187
LEU A 191
 None
 1.06A 4qzuC-2cukA:
undetectable		 4qzuC-2cukA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 7 GLY A 251
LEU A 252
LEU A 210
GLY A 249
LEU A 247
 None
 1.36A 5vkqA-2cukA:
undetectable
5vkqB-2cukA:
undetectable		 5vkqA-2cukA:
12.16
5vkqB-2cukA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		6 / 8 GLY A 251
LEU A 252
LEU A 210
VAL A 234
GLY A 249
LEU A 247
 None
 1.37A 5vkqB-2cukA:
undetectable
5vkqC-2cukA:
undetectable		 5vkqB-2cukA:
12.16
5vkqC-2cukA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		6 / 9 GLY A 251
LEU A 252
LEU A 210
VAL A 234
GLY A 249
LEU A 247
 None
 1.40A 5vkqC-2cukA:
undetectable
5vkqD-2cukA:
undetectable		 5vkqC-2cukA:
12.16
5vkqD-2cukA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0B-2cukA:
undetectable		 6ew0B-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.12A 6ew0D-2cukA:
undetectable		 6ew0D-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0F-2cukA:
2.1		 6ew0F-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0G-2cukA:
undetectable		 6ew0G-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.13A 6ew0H-2cukA:
2.0		 6ew0H-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A  53
LEU A  22
ALA A  70
LEU A 301
LEU A  66
 None
 1.12A 6ew0I-2cukA:
2.0		 6ew0I-2cukA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		4 / 4 MET A 152
GLY A 156
HIS A 200
GLY A 151
 None
 1.43A 6fgdA-2cukA:
3.7		 6fgdA-2cukA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE
(Thermus
thermophilus) 		5 / 10 SER A 198
ALA A 108
LEU A 109
GLY A 251
LEU A  30
 None
 1.33A 6hqbA-2cukA:
undetectable
6hqbJ-2cukA:
undetectable		 6hqbA-2cukA:
17.41
6hqbJ-2cukA:
10.19