SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.20A 1d4fA-2culA:
3.1		 1d4fA-2culA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.26A 1d4fB-2culA:
3.2		 1d4fB-2culA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.23A 1d4fD-2culA:
3.2		 1d4fD-2culA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  96
VAL A 101
VAL A 121
LEU A 119
LEU A 125
 None
None
FAD  A 301 (-3.8A)
None
None
 1.28A 1mx1E-2culA:
undetectable		 1mx1E-2culA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		6 / 12 GLY A 122
GLY A 220
GLY A  15
GLY A  12
THR A  18
LEU A  22
 FAD  A 301 (-3.2A)
None
None
FAD  A 301 (-3.1A)
None
None
 1.30A 2oxtB-2culA:
undetectable		 2oxtB-2culA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 8 ALA A  89
GLY A  30
LEU A   7
GLY A 103
 None
 0.67A 2yfxA-2culA:
undetectable		 2yfxA-2culA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A 120
GLY A 122
PHE A  13
SER A  14
LEU A 223
 None
FAD  A 301 (-3.2A)
FAD  A 301 (-4.8A)
FAD  A 301 (-2.7A)
None
 1.13A 3bxoA-2culA:
3.1		 3bxoA-2culA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 181
TYR A 180
GLY A 139
GLY A 126
LEU A 150
 None
FAD  A 301 ( 4.7A)
None
None
None
 1.19A 3e23A-2culA:
3.5		 3e23A-2culA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.19A 3g1uA-2culA:
3.2		 3g1uA-2culA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.21A 3g1uB-2culA:
3.5		 3g1uB-2culA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.19A 3g1uC-2culA:
3.2		 3g1uC-2culA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.19A 3g1uD-2culA:
3.2		 3g1uD-2culA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.15A 3glqA-2culA:
2.4		 3glqA-2culA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.15A 3glqB-2culA:
3.2		 3glqB-2culA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 195
LEU A  96
LEU A  94
GLY A  93
PHE A 183
 None
 1.21A 3n58A-2culA:
2.8		 3n58A-2culA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 4 GLY A  12
GLY A  10
THR A  33
LEU A  86
 FAD  A 301 (-3.1A)
FAD  A 301 (-3.2A)
FAD  A 301 (-4.2A)
None
 0.85A 3si7C-2culA:
undetectable
3si7D-2culA:
undetectable		 3si7C-2culA:
21.28
3si7D-2culA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 8 GLY A  12
SER A  14
GLY A 220
ILE A   8
VAL A 204
 FAD  A 301 (-3.1A)
FAD  A 301 (-2.7A)
None
None
None
 1.30A 3v1nA-2culA:
undetectable		 3v1nA-2culA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 8 ALA A  19
VAL A   6
GLY A 220
VAL A   9
ILE A   8
 None
 1.42A 4ll3A-2culA:
undetectable		 4ll3A-2culA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 10 LEU A  81
LEU A  22
ALA A  23
LEU A 223
ALA A 224
 None
 1.20A 4zbrA-2culA:
undetectable		 4zbrA-2culA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 4 GLY A 122
ALA A 120
MET A  40
THR A  18
 FAD  A 301 (-3.2A)
None
None
None
 1.27A 5n0sB-2culA:
undetectable		 5n0sB-2culA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A  38
GLY A 139
GLY A  15
ALA A  16
SER A 123
 FAD  A 301 ( 4.8A)
None
None
None
FAD  A 301 ( 4.1A)
 0.91A 5w4zA-2culA:
0.5		 5w4zA-2culA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A  38
GLY A 139
GLY A  15
ALA A  16
SER A 123
 FAD  A 301 ( 4.8A)
None
None
None
FAD  A 301 ( 4.1A)
 0.92A 5w4zB-2culA:
0.5		 5w4zB-2culA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE
(Thermus
thermophilus) 		3 / 3 ARG A 197
LYS A 196
ARG A 222
 None
 1.35A 6c06D-2culA:
undetectable		 6c06D-2culA:
undetectable