SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 6 LEU A  84
ILE A 253
GLU A  92
PRO A 220
 None
 1.22A 1ditH-2cuyA:
undetectable
1ditP-2cuyA:
undetectable		 1ditH-2cuyA:
20.36
1ditP-2cuyA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 127
GLU A 126
GLY A 125
VAL A 122
GLY A 149
 None
 0.94A 1n2xB-2cuyA:
undetectable		 1n2xB-2cuyA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		3 / 3 ALA A 227
VAL A 248
TRP A 250
 None
 0.95A 1nrmA-2cuyA:
undetectable		 1nrmA-2cuyA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		3 / 3 ALA A 227
VAL A 248
TRP A 250
 None
 0.95A 1nrmB-2cuyA:
undetectable		 1nrmB-2cuyA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 5 ALA A  70
TYR A  71
ALA A  66
TYR A  68
 None
 1.11A 1xl6A-2cuyA:
undetectable
1xl6B-2cuyA:
undetectable		 1xl6A-2cuyA:
21.54
1xl6B-2cuyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 7 ARG A 260
ALA A  86
ASP A 256
TYR A 222
 None
 1.12A 2e5dA-2cuyA:
undetectable
2e5dB-2cuyA:
undetectable		 2e5dA-2cuyA:
21.31
2e5dB-2cuyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 7 ASP A 256
TYR A 222
ARG A 260
ALA A  86
 None
 1.12A 2e5dA-2cuyA:
undetectable
2e5dB-2cuyA:
undetectable		 2e5dA-2cuyA:
21.31
2e5dB-2cuyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 10 ALA A  70
ALA A  27
GLU A  76
ALA A  73
TYR A  71
 None
 1.42A 2r2vC-2cuyA:
undetectable
2r2vF-2cuyA:
undetectable
2r2vG-2cuyA:
undetectable		 2r2vC-2cuyA:
8.55
2r2vF-2cuyA:
8.55
2r2vG-2cuyA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 SER A 196
GLN A  60
THR A  56
ILE A 244
SER A  89
 None
 1.45A 2vdyB-2cuyA:
undetectable		 2vdyB-2cuyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 4 ALA A  70
TYR A  71
ALA A  66
TYR A  68
 None
 1.12A 2wlkA-2cuyA:
undetectable
2wlkB-2cuyA:
undetectable		 2wlkA-2cuyA:
21.54
2wlkB-2cuyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 7 GLU A 231
ALA A  95
PRO A 217
ALA A  99
 None
 1.13A 2zgwA-2cuyA:
undetectable		 2zgwA-2cuyA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 6 GLU A 231
ALA A  95
PRO A 217
ALA A  99
 None
 1.14A 2zgwB-2cuyA:
undetectable		 2zgwB-2cuyA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 5 ILE A 163
SER A 164
PHE A 193
PRO A 192
 None
 1.39A 3bjwC-2cuyA:
0.9		 3bjwC-2cuyA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 9 LEU A 147
VAL A 150
VAL A 132
ILE A 152
VAL A 185
 None
 1.36A 3cs9C-2cuyA:
undetectable		 3cs9C-2cuyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 11 LEU A 144
VAL A 170
ILE A 140
ALA A 130
ALA A 153
 None
 1.13A 3mdtB-2cuyA:
undetectable		 3mdtB-2cuyA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 108
LEU A  31
ARG A  33
GLY A  17
SER A 270
 None
 1.16A 3okxA-2cuyA:
undetectable		 3okxA-2cuyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 TYR A 222
ASN A 224
ALA A 107
PHE A   6
LEU A  64
 None
 1.11A 3vywA-2cuyA:
undetectable		 3vywA-2cuyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 TYR A 222
ASN A 224
ALA A 107
PHE A   6
LEU A  64
 None
 1.11A 3vywB-2cuyA:
undetectable		 3vywB-2cuyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 TYR A 222
ASN A 224
ALA A 107
PHE A   6
LEU A  64
 None
 1.08A 3vywC-2cuyA:
undetectable		 3vywC-2cuyA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 10 ALA A  34
LEU A  38
GLY A  40
ALA A 201
MET A 198
 None
 1.47A 4fe1A-2cuyA:
undetectable
4fe1J-2cuyA:
undetectable		 4fe1A-2cuyA:
17.08
4fe1J-2cuyA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 ALA A  34
GLU A  35
LEU A  44
LEU A  53
LEU A  64
 None
 1.17A 4j24D-2cuyA:
undetectable		 4j24D-2cuyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  64
LEU A 110
ILE A 244
LEU A 205
HIS A 194
 None
 1.21A 4j24D-2cuyA:
undetectable		 4j24D-2cuyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 8 ALA A  66
LEU A 108
LEU A 104
LEU A  42
LEU A  41
 None
 1.35A 5jqbA-2cuyA:
undetectable
5jqbB-2cuyA:
undetectable		 5jqbA-2cuyA:
21.17
5jqbB-2cuyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 8 GLN A   9
ASN A 154
ALA A 153
HIS A  88
 None
 1.13A 5km8A-2cuyA:
undetectable
5km8B-2cuyA:
undetectable		 5km8A-2cuyA:
22.41
5km8B-2cuyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  64
LEU A 110
ILE A 244
LEU A 205
HIS A 194
 None
 1.23A 5toaB-2cuyA:
undetectable		 5toaB-2cuyA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 5 LEU A 274
LEU A 277
MET A 257
TYR A   2
 None
 1.43A 5uc3A-2cuyA:
undetectable		 5uc3A-2cuyA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 MET A  45
GLY A 269
SER A 270
GLU A 267
LEU A  63
 None
 1.33A 5vlmF-2cuyA:
undetectable		 5vlmF-2cuyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		5 / 12 MET A  45
GLY A 269
SER A 270
GLU A 267
PHE A   6
 None
 1.41A 5vlmF-2cuyA:
undetectable		 5vlmF-2cuyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 8 LEU A  44
LEU A  41
GLY A 115
ARG A 114
 None
 0.90A 6ce2A-2cuyA:
0.9		 6ce2A-2cuyA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 205
LEU A 209
LEU A  90
GLY A  91
 None
 0.93A 6ce2A-2cuyA:
0.9		 6ce2A-2cuyA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE
(Thermus
thermophilus) 		3 / 3 HIS A 194
ARG A 114
ILE A 244
 None
 0.86A 6fgdA-2cuyA:
2.3		 6fgdA-2cuyA:
23.29