SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2cv8 TRNA-SPLICING
ENDONUCLEASE
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A  20
ARG A  19
ILE A  21
 None
 0.66A 2xn5B-2cv8A:
undetectable		 2xn5B-2cv8A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2cv8 TRNA-SPLICING
ENDONUCLEASE
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A  69
GLY A  68
LEU A  71
GLU A   4
 None
 1.01A 3w9tB-2cv8A:
undetectable		 3w9tB-2cv8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2cv8 TRNA-SPLICING
ENDONUCLEASE
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A  69
GLY A  68
LEU A  71
GLU A   4
 None
 1.01A 3w9tE-2cv8A:
undetectable		 3w9tE-2cv8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2cv8 TRNA-SPLICING
ENDONUCLEASE
(Sulfurisphaera
tokodaii) 		5 / 10 ASP A 113
GLU A 135
VAL A 163
ILE A 170
TYR A 172
 None
 1.35A 4qt2A-2cv8A:
undetectable		 4qt2A-2cv8A:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2cv8 TRNA-SPLICING
ENDONUCLEASE
(Sulfurisphaera
tokodaii) 		5 / 10 ASP A 113
VAL A 163
ILE A 170
TYR A 172
LEU A  97
 None
 1.21A 5hw8C-2cv8A:
undetectable
5hw8H-2cv8A:
undetectable		 5hw8C-2cv8A:
26.32
5hw8H-2cv8A:
26.32