SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 6 GLU A 191
THR A 156
ALA A 131
ALA A 165
 None
 1.11A 3ns1C-2cveA:
undetectable		 3ns1C-2cveA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		5 / 12 GLY A 103
GLY A 100
GLN A  16
ALA A 107
TYR A 108
 None
TLA  A 192 (-3.5A)
None
None
None
 1.39A 3t7sC-2cveA:
undetectable		 3t7sC-2cveA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		5 / 12 LEU A 104
LEU A  99
PHE A  20
GLU A  65
HIS A  47
 TLA  A 192 (-4.5A)
TLA  A 192 (-4.3A)
None
TLA  A 192 (-3.1A)
None
 0.94A 4aqlA-2cveA:
undetectable		 4aqlA-2cveA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 8 VAL A  10
PHE A  36
LEU A  89
LYS A   8
 None
 1.07A 4f8hA-2cveA:
undetectable
4f8hB-2cveA:
undetectable		 4f8hA-2cveA:
21.47
4f8hB-2cveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 8 VAL A  10
PHE A  36
LEU A  89
LYS A   8
 None
 1.06A 4f8hB-2cveA:
undetectable
4f8hC-2cveA:
undetectable		 4f8hB-2cveA:
21.47
4f8hC-2cveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 8 VAL A  10
PHE A  36
LEU A  89
LYS A   8
 None
 1.07A 4f8hC-2cveA:
undetectable
4f8hD-2cveA:
undetectable		 4f8hC-2cveA:
21.47
4f8hD-2cveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 8 VAL A  10
PHE A  36
LEU A  89
LYS A   8
 None
 1.06A 4f8hD-2cveA:
undetectable
4f8hE-2cveA:
undetectable		 4f8hD-2cveA:
21.47
4f8hE-2cveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 8 VAL A  10
PHE A  36
LEU A  89
LYS A   8
 None
 1.06A 4f8hA-2cveA:
undetectable
4f8hE-2cveA:
undetectable		 4f8hA-2cveA:
21.47
4f8hE-2cveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		4 / 4 VAL A 162
THR A 156
GLU A 155
GLU A 154
 None
 1.32A 4l78A-2cveA:
4.8		 4l78A-2cveA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		5 / 12 LEU A 104
PRO A  73
VAL A  90
GLY A  49
GLY A  71
 TLA  A 192 (-4.5A)
None
None
None
None
 0.93A 5nnaC-2cveA:
undetectable		 5nnaC-2cveA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cve HYPOTHETICAL PROTEIN
TTHA1053
(Thermus
thermophilus) 		3 / 3 LEU A 166
ALA A 165
LEU A 146
 None
 0.48A 5uunB-2cveA:
undetectable		 5uunB-2cveA:
23.24