SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		3 / 3 ASP A 178
ILE A 147
VAL A 111
 None
 0.65A 2avvD-2cvhA:
undetectable		 2avvD-2cvhA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		4 / 8 VAL A 110
VAL A  25
THR A  40
VAL A  48
 None
 0.97A 3fhxB-2cvhA:
2.9		 3fhxB-2cvhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		5 / 12 GLY A  32
LEU A 108
GLY A  45
PHE A  17
THR A  35
 None
 1.32A 4ze1A-2cvhA:
undetectable		 4ze1A-2cvhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		4 / 7 ALA A  76
ARG A 214
GLY A 215
GLU A 217
 None
 0.76A 5btgA-2cvhA:
undetectable
5btgC-2cvhA:
undetectable
5btgD-2cvhA:
undetectable		 5btgA-2cvhA:
20.87
5btgC-2cvhA:
20.87
5btgD-2cvhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		4 / 8 LEU A  22
ILE A 179
THR A 115
LEU A 131
 None
 0.78A 5eseA-2cvhA:
undetectable		 5eseA-2cvhA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		4 / 8 GLY A  16
THR A   4
LEU A  36
LEU A 182
 None
 0.87A 5hs1A-2cvhA:
undetectable		 5hs1A-2cvhA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		4 / 4 LEU A 182
MET A 206
ILE A 211
LEU A 185
 None
 1.22A 5nfpA-2cvhA:
undetectable		 5nfpA-2cvhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		5 / 8 VAL A  48
LEU A 108
ILE A 150
ILE A 152
SER A  58
 None
 1.30A 5numA-2cvhA:
undetectable		 5numA-2cvhA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB
(Thermococcus
kodakarensis) 		5 / 12 THR A 115
THR A  53
PRO A  85
LEU A 108
ASN A 153
 None
 1.37A 5ybbB-2cvhA:
2.9		 5ybbB-2cvhA:
17.19