SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.98A 1hxwB-2cvjA:
undetectable		 1hxwB-2cvjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		6 / 11 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
VAL A 167
 None
 1.06A 1t7jA-2cvjA:
undetectable		 1t7jA-2cvjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 8 THR A 133
THR A 106
LEU A 118
VAL A   7
 None
FAD  A2304 (-4.3A)
None
FAD  A2304 (-4.9A)
 0.63A 1t86A-2cvjA:
undetectable		 1t86A-2cvjA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  68
VAL A  73
GLY A  10
 None
None
FAD  A2304 (-3.4A)
 0.65A 2avvE-2cvjA:
undetectable		 2avvE-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 2f81A-2cvjA:
undetectable		 2f81A-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.99A 2f81B-2cvjA:
undetectable		 2f81B-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.97A 2f8gA-2cvjA:
undetectable		 2f8gA-2cvjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 7 ALA A 144
GLY A 150
ILE A 154
PRO A  11
 None
FAD  A2304 (-3.4A)
None
FAD  A2304 (-3.9A)
 0.76A 2fxdB-2cvjA:
undetectable		 2fxdB-2cvjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 167
 None
 0.72A 2ieoB-2cvjA:
undetectable		 2ieoB-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 167
 None
 0.76A 2nnkA-2cvjA:
undetectable		 2nnkA-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 102
LEU A 166
CYH A 105
THR A 106
 None
None
None
FAD  A2304 (-4.3A)
 1.39A 2oaxD-2cvjA:
undetectable		 2oaxD-2cvjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 3cywB-2cvjA:
undetectable		 3cywB-2cvjA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.97A 3d1zB-2cvjA:
undetectable		 3d1zB-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 3d20A-2cvjA:
undetectable		 3d20A-2cvjA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.97A 3ektA-2cvjA:
undetectable		 3ektA-2cvjA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.96A 3ektD-2cvjA:
undetectable		 3ektD-2cvjA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		6 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
VAL A 167
 None
 1.00A 3gguA-2cvjA:
undetectable		 3gguA-2cvjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.93A 3lzsA-2cvjA:
undetectable		 3lzsA-2cvjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 3lzsB-2cvjA:
undetectable		 3lzsB-2cvjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.93A 3lzuA-2cvjA:
undetectable		 3lzuA-2cvjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 1.05A 3mwsA-2cvjA:
undetectable		 3mwsA-2cvjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.98A 3ndtD-2cvjA:
undetectable		 3ndtD-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 1.00A 3nu5B-2cvjA:
undetectable		 3nu5B-2cvjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 3nu6B-2cvjA:
undetectable		 3nu6B-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		6 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
VAL A 167
 None
 0.98A 3nu9B-2cvjA:
undetectable		 3nu9B-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 3nujB-2cvjA:
undetectable		 3nujB-2cvjA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 3nuoB-2cvjA:
undetectable		 3nuoB-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.96A 3oxvC-2cvjA:
undetectable		 3oxvC-2cvjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 3oxwA-2cvjA:
undetectable		 3oxwA-2cvjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.99A 3oy4B-2cvjA:
undetectable		 3oy4B-2cvjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 1.00A 3pwmA-2cvjA:
undetectable		 3pwmA-2cvjA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.97A 3tkgD-2cvjA:
undetectable		 3tkgD-2cvjA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.96A 3tkwA-2cvjA:
undetectable		 3tkwA-2cvjA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 167
 None
 0.66A 3u7sA-2cvjA:
undetectable		 3u7sA-2cvjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 4dqbB-2cvjA:
undetectable		 4dqbB-2cvjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 4dqcB-2cvjA:
undetectable		 4dqcB-2cvjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 4dqeB-2cvjA:
undetectable		 4dqeB-2cvjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.96A 4dqhB-2cvjA:
undetectable		 4dqhB-2cvjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.98A 4njtB-2cvjA:
undetectable		 4njtB-2cvjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 1.00A 4njtD-2cvjA:
undetectable		 4njtD-2cvjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.94A 4rvjD-2cvjA:
undetectable		 4rvjD-2cvjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 120
ASP A 126
ARG A 121
 None
 0.68A 4wq4B-2cvjA:
undetectable		 4wq4B-2cvjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 8 ALA A 141
GLY A 159
ALA A  16
GLY A  13
 None
 0.66A 4zjzA-2cvjA:
undetectable		 4zjzA-2cvjA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 4 GLY A 142
CYH A 105
ARG A 145
GLY A 159
 FAD  A2304 ( 4.1A)
None
None
None
 0.95A 5inzA-2cvjA:
undetectable
5inzC-2cvjA:
undetectable
5inzD-2cvjA:
undetectable		 5inzA-2cvjA:
13.25
5inzC-2cvjA:
13.25
5inzD-2cvjA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 1.01A 5kr0B-2cvjA:
undetectable		 5kr0B-2cvjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		3 / 3 THR A 106
THR A  92
LEU A  28
 FAD  A2304 (-4.3A)
None
None
 0.71A 5m66D-2cvjA:
3.1		 5m66D-2cvjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 5t2zA-2cvjA:
undetectable		 5t2zA-2cvjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 144
GLY A 146
LYS A 147
GLY A   9
ASP A 158
 None
None
None
FAD  A2304 ( 4.8A)
None
 1.22A 5wwsB-2cvjA:
undetectable		 5wwsB-2cvjA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 6dgxA-2cvjA:
undetectable		 6dgxA-2cvjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		6 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
VAL A 167
 None
 1.03A 6dh0A-2cvjA:
undetectable		 6dh0A-2cvjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 6dh3A-2cvjA:
undetectable		 6dh3A-2cvjA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 170
GLY A  24
ALA A  23
ASP A 177
VAL A 164
 None
 0.95A 6dh6A-2cvjA:
undetectable		 6dh6A-2cvjA:
15.43