SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR
(Thermus
thermophilus) 		4 / 6 TYR A  16
ILE A  32
PRO A 110
GLU A 116
 None
 0.68A 1oniA-2cvlA:
22.5
1oniC-2cvlA:
22.7		 1oniA-2cvlA:
40.15
1oniC-2cvlA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR
(Thermus
thermophilus) 		4 / 7 TYR A  16
ILE A  32
PRO A 110
GLU A 116
 None
 0.84A 1oniD-2cvlA:
22.9
1oniE-2cvlA:
22.9		 1oniD-2cvlA:
40.15
1oniE-2cvlA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ATT_A_ACTA1209_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR
(Thermus
thermophilus) 		4 / 4 ASP A  82
ARG A 114
ASP A  79
GLU A  81
 None
 0.71A 3attA-2cvlA:
0.0		 3attA-2cvlA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR
(Thermus
thermophilus) 		3 / 3 ALA A  58
VAL A  59
GLN A  18
 None
 0.72A 3of4B-2cvlA:
undetectable		 3of4B-2cvlA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR
(Thermus
thermophilus) 		5 / 9 ALA A  19
ALA A   3
ALA A  17
GLY A  64
ALA A  62
 None
 0.95A 5l5zK-2cvlA:
undetectable
5l5zL-2cvlA:
undetectable		 5l5zK-2cvlA:
21.57
5l5zL-2cvlA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR
(Thermus
thermophilus) 		5 / 9 ALA A  19
ALA A   3
ALA A  17
GLY A  64
ALA A  62
 None
 0.95A 5l5zY-2cvlA:
undetectable
5l5zZ-2cvlA:
undetectable		 5l5zY-2cvlA:
21.57
5l5zZ-2cvlA:
19.28