SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 7 GLY A 184
ASP A 170
HIS A 148
ALA A 169
 None
 0.88A 1gxsA-2cvoA:
undetectable
1gxsB-2cvoA:
undetectable		 1gxsA-2cvoA:
19.03
1gxsB-2cvoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 6 THR A 353
ASN A 383
LEU A 384
ASP A 382
 None
 0.81A 1mxdA-2cvoA:
undetectable		 1mxdA-2cvoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 8 THR A 353
ASN A 383
LEU A 384
ASP A 382
 None
 0.88A 1mxgA-2cvoA:
undetectable		 1mxgA-2cvoA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 5 VAL A 139
ASN A 138
VAL A 102
ILE A  75
 None
 0.93A 1z2bC-2cvoA:
4.1		 1z2bC-2cvoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 12 GLY A  79
GLY A  82
VAL A 131
LEU A 146
PRO A 147
 CSO  A 145 ( 3.2A)
None
None
CSO  A 145 ( 3.5A)
None
 0.86A 1zq9B-2cvoA:
4.1		 1zq9B-2cvoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 4 GLN A 225
GLU A 285
ILE A 284
PRO A 221
 None
 1.49A 2fcnA-2cvoA:
undetectable		 2fcnA-2cvoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 6 LEU A 328
VAL A 366
ILE A 377
MET A 319
ILE A 237
 None
 1.21A 2piwA-2cvoA:
undetectable		 2piwA-2cvoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 10 VAL A 385
GLU A  87
GLY A 387
THR A 201
ARG A  90
 None
 1.29A 3bjwD-2cvoA:
0.0		 3bjwD-2cvoA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 12 ILE A 155
ALA A 189
LEU A 192
VAL A 142
LEU A 146
 None
None
None
None
CSO  A 145 ( 3.5A)
 1.10A 3dzyA-2cvoA:
undetectable		 3dzyA-2cvoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 7 VAL A 281
LEU A 288
SER A 289
VAL A 239
 None
 0.87A 3hs6B-2cvoA:
undetectable		 3hs6B-2cvoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		4 / 5 PHE A 171
ILE A 155
GLY A 149
HIS A 187
 None
 1.16A 3r0lD-2cvoA:
undetectable		 3r0lD-2cvoA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 12 PHE A 143
ALA A 392
LEU A 408
PHE A  98
GLY A 407
 None
 1.11A 4dm8B-2cvoA:
undetectable		 4dm8B-2cvoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		3 / 3 LYS A 146
THR A 151
ILE A 164
 CSO  A 145 ( 3.6A)
None
None
 0.79A 4e0fB-2cvoA:
undetectable		 4e0fB-2cvoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 12 ALA A  80
THR A 151
ILE A 154
LEU A 158
PRO A 159
 None
 0.98A 4p3qA-2cvoA:
undetectable		 4p3qA-2cvoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		3 / 3 ILE A 154
ASP A 106
ARG A 188
 None
 0.79A 4pstA-2cvoA:
undetectable		 4pstA-2cvoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		3 / 3 TYR A  83
TYR A 273
SER A 248
 None
 0.70A 5iktB-2cvoA:
undetectable		 5iktB-2cvoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 7 LEU A 167
GLY A  85
GLY A  82
SER A 168
ALA A 388
 CSO  A 145 ( 4.9A)
None
None
None
None
 1.24A 5o96C-2cvoA:
2.6		 5o96C-2cvoA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 10 ALA A 260
LEU A 304
TYR A 273
VAL A 250
GLY A 252
 None
 1.41A 5zbdA-2cvoA:
undetectable		 5zbdA-2cvoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE
(Oryza
sativa) 		5 / 10 ALA A 260
LEU A 304
TYR A 273
VAL A 250
GLY A 252
 None
 1.44A 5zbdB-2cvoA:
undetectable		 5zbdB-2cvoA:
21.20