SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 180
ASN A 175
SER A 207
ILE A 288
LEU A 219
 None
 1.17A 1lhuA-2cvzA:
undetectable		 1lhuA-2cvzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 PRO A  64
GLY A   8
ASN A  30
GLY A  10
 NDP  A1302 (-4.0A)
NDP  A1302 (-3.4A)
NDP  A1302 (-3.1A)
NDP  A1302 (-3.3A)
 1.16A 1zlqA-2cvzA:
undetectable		 1zlqA-2cvzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU A 277
ILE A 200
VAL A 218
ILE A 288
 None
 0.77A 2aojB-2cvzA:
undetectable		 2aojB-2cvzA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 205
LEU A 171
LEU A 172
THR A 210
ALA A 209
 None
 1.07A 2egvB-2cvzA:
2.5		 2egvB-2cvzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 161
GLY A 159
ASP A 113
ALA A 114
HIS A 154
 None
 0.88A 2gluA-2cvzA:
5.6		 2gluA-2cvzA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ALA A 123
ALA A  89
ALA A 114
VAL A 152
 None
 0.92A 2nyrB-2cvzA:
4.1		 2nyrB-2cvzA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 GLY A 159
GLY A 133
GLY A 156
GLY A 161
 None
 0.55A 3bogC-2cvzA:
undetectable		 3bogC-2cvzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 GLY A 159
GLY A 133
GLY A 156
GLY A 161
 None
 0.56A 3bogD-2cvzA:
undetectable		 3bogD-2cvzA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ASP A 244
GLY A 245
LYS A 247
GLU A 246
 None
 1.16A 3hznD-2cvzA:
undetectable		 3hznD-2cvzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
GLY A  13
PHE A  60
THR A  65
LEU A  63
 NDP  A1302 (-3.4A)
None
None
None
NDP  A1302 (-4.2A)
 1.05A 3mteB-2cvzA:
3.1		 3mteB-2cvzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
GLY A  13
PHE A  60
THR A  65
LEU A  63
 NDP  A1302 (-3.4A)
None
None
None
NDP  A1302 (-4.2A)
 0.96A 3p2kA-2cvzA:
3.7		 3p2kA-2cvzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ILE A 200
GLY A 205
SER A 204
SER A 203
 None
 0.90A 3v7pA-2cvzA:
undetectable		 3v7pA-2cvzA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A 221
PHE A 223
PRO A 224
 None
 0.80A 3zoaB-2cvzA:
undetectable		 3zoaB-2cvzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 THR A 210
LEU A 186
LEU A 183
GLY A 182
 None
 0.85A 4c9nA-2cvzA:
undetectable		 4c9nA-2cvzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 161
GLY A 159
LEU A 128
SER A 117
ASP A  88
 None
 1.03A 4fp9A-2cvzA:
3.5		 4fp9A-2cvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 161
GLY A 159
LEU A 128
SER A 117
ASP A  88
 None
 1.04A 4fp9C-2cvzA:
3.5		 4fp9C-2cvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 161
GLY A 159
LEU A 128
SER A 117
ASP A  88
 None
 1.04A 4fp9F-2cvzA:
3.5		 4fp9F-2cvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 HIS A 273
ASP A 272
GLU A 275
LEU A 213
LEU A 176
 None
 1.30A 4pgfB-2cvzA:
4.4		 4pgfB-2cvzA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 139
GLY A 161
GLY A 159
VAL A 155
HIS A 154
 None
 0.70A 4qdjA-2cvzA:
4.7		 4qdjA-2cvzA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLU A 194
ILE A 214
ARG A 206
ILE A 200
 None
 0.86A 4xumA-2cvzA:
undetectable		 4xumA-2cvzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 SER A 117
GLY A 119
ASP A 272
HIS A 273
LEU A 232
 None
NDP  A1302 (-3.6A)
None
None
None
 1.43A 5eeiA-2cvzA:
undetectable		 5eeiA-2cvzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 SER A 117
GLY A 119
ASP A 272
HIS A 273
LEU A 232
 None
NDP  A1302 (-3.6A)
None
None
None
 1.43A 5eeiB-2cvzA:
undetectable		 5eeiB-2cvzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLU A 281
GLY A 180
VAL A 274
ARG A 278
ALA A 263
 None
 1.12A 5o96A-2cvzA:
2.0
5o96B-2cvzA:
3.2		 5o96A-2cvzA:
20.26
5o96B-2cvzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LEU A 176
ALA A 173
LEU A 277
 None
 0.47A 5uunB-2cvzA:
undetectable		 5uunB-2cvzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  63
LEU A   9
ALA A   5
ALA A  17
ILE A  59
 NDP  A1302 (-4.2A)
None
None
None
None
 0.88A 5xiwB-2cvzA:
3.8		 5xiwB-2cvzA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 HIS A  39
ALA A  47
SER A  45
GLY A  44
 None
 1.18A 5yodB-2cvzA:
undetectable		 5yodB-2cvzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 HIS A  39
ALA A  47
SER A  45
GLY A  44
 None
 1.22A 5yodD-2cvzA:
undetectable		 5yodD-2cvzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ASN A 169
ALA A 166
LYS A 234
LEU A 232
 None
None
NDP  A1302 (-2.9A)
None
 1.07A 6ci6A-2cvzA:
undetectable		 6ci6A-2cvzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A  60
ALA A  17
TYR A  14
VAL A  28
VAL A  53
 None
 1.41A 6hu9N-2cvzA:
undetectable		 6hu9N-2cvzA:
19.60