SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		5 / 9 LEU A 102
ALA A 134
GLY A 200
ALA A 199
LEU A 158
 None
 1.01A 1nr6A-2cw2A:
undetectable		 1nr6A-2cw2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 5 LEU A 102
TRP A 189
MET A 159
LEU A 158
 None
 1.49A 1p93D-2cw2A:
undetectable		 1p93D-2cw2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		5 / 12 ILE A  46
ILE A  53
ILE A  62
VAL A  77
LEU A  59
 None
 1.06A 1qhyA-2cw2A:
undetectable		 1qhyA-2cw2A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 6 TYR A 183
TRP A 164
TYR A 179
HIS A  35
 None
 1.34A 2xudA-2cw2A:
undetectable		 2xudA-2cw2A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 7 ASN A 149
GLY A 148
VAL A 142
ASP A 146
 None
 0.80A 2y05A-2cw2A:
undetectable
2y05B-2cw2A:
undetectable		 2y05A-2cw2A:
21.10
2y05B-2cw2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 8 PHE A 113
PRO A  95
GLY A  93
MET A 159
 None
 0.79A 2y6rB-2cw2A:
undetectable		 2y6rB-2cw2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		5 / 10 PHE A 113
VAL A 192
ASN A  86
PHE A  82
ASN A 149
 None
 1.37A 3r6wA-2cw2A:
undetectable
3r6wB-2cw2A:
undetectable		 3r6wA-2cw2A:
22.45
3r6wB-2cw2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 7 PHE A  83
ASN A 160
HIS A 166
HIS A  31
 None
None
FE  A 402 (-3.1A)
FE  A 402 (-3.1A)
 1.08A 3t01A-2cw2A:
undetectable		 3t01A-2cw2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 8 ASN A  85
PHE A 191
PHE A  84
TYR A 183
 None
 1.17A 4v2zC-2cw2A:
0.0		 4v2zC-2cw2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		4 / 8 HIS A 145
GLY A 148
GLY A 144
HIS A 124
 None
 0.78A 5f8yB-2cw2A:
undetectable		 5f8yB-2cw2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2cw2 SUPEROXIDE DISMUTASE
1
(Perkinsus
marinus) 		3 / 3 LYS A 114
GLN A 178
ASN A 182
 None
 0.94A 5l2tA-2cw2A:
undetectable		 5l2tA-2cw2A:
21.38