SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 7 ASP A 182
PHE A 184
ASN A 186
SER A 227
 None
 1.07A 1rqpB-2cw5A:
23.2		 1rqpB-2cw5A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 8 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
 None
 1.00A 1rqpC-2cw5A:
23.2		 1rqpC-2cw5A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 8 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
 None
 0.98A 1rqpA-2cw5A:
23.2		 1rqpA-2cw5A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 5 PRO A  29
LEU A 147
GLY A 148
LYS A   1
 None
 1.36A 1ya4C-2cw5A:
undetectable		 1ya4C-2cw5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 8 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
 None
 0.96A 2v7uA-2cw5A:
23.2		 2v7uA-2cw5A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 7 ASP A 182
PHE A 184
ASN A 186
SER A 227
 None
 1.07A 2v7uB-2cw5A:
23.1		 2v7uB-2cw5A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1300_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		6 / 9 ASP A 182
PHE A 184
ASN A 186
SER A 227
ALA A 234
ASN A 236
 None
 0.91A 2v7uC-2cw5A:
23.2		 2v7uC-2cw5A:
29.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 7 LEU A  98
LEU A 101
LEU A 179
GLU A 177
 None
 0.98A 2vq5B-2cw5A:
undetectable		 2vq5B-2cw5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 4 GLY A  62
GLU A  61
ASP A 103
TYR A  88
 None
 1.35A 2yvlC-2cw5A:
undetectable		 2yvlC-2cw5A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 9 ALA A  81
VAL A  89
GLY A  90
LEU A 154
ALA A 141
 None
 0.71A 2z0yA-2cw5A:
2.1		 2z0yA-2cw5A:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 9 ALA A  81
VAL A  89
GLY A  90
LEU A 154
ALA A 141
 None
 0.77A 2z0yB-2cw5A:
3.2		 2z0yB-2cw5A:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 8 LEU A 254
ARG A 253
GLY A 197
PRO A 195
 None
 0.95A 3ny4A-2cw5A:
undetectable		 3ny4A-2cw5A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 8 GLU A 175
LEU A 230
VAL A 200
LEU A 254
 None
 0.97A 4r38B-2cw5A:
undetectable		 4r38B-2cw5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 12 GLY A 214
GLU A 215
LEU A 246
ARG A 241
ALA A 243
 None
 1.08A 4wcxC-2cw5A:
undetectable		 4wcxC-2cw5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 11 LEU A 230
LEU A 179
LEU A 170
ALA A  99
LEU A  98
 None
 1.21A 4wg0H-2cw5A:
undetectable
4wg0I-2cw5A:
undetectable
4wg0J-2cw5A:
undetectable		 4wg0H-2cw5A:
8.76
4wg0I-2cw5A:
8.76
4wg0J-2cw5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 11 ALA A  99
LEU A  98
LEU A 170
LEU A 230
LEU A 179
 None
 1.16A 4wg0I-2cw5A:
undetectable
4wg0J-2cw5A:
undetectable
4wg0K-2cw5A:
undetectable		 4wg0I-2cw5A:
8.76
4wg0J-2cw5A:
8.76
4wg0K-2cw5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 12 ALA A  81
THR A  87
LEU A 154
PRO A  91
ALA A  79
 None
 0.89A 4ypmA-2cw5A:
undetectable		 4ypmA-2cw5A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 12 GLY A  62
ILE A 188
GLY A 226
GLY A 229
LEU A 102
 None
 1.03A 5eqbA-2cw5A:
undetectable		 5eqbA-2cw5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		5 / 7 GLY A 238
GLY A 185
PHE A 181
VAL A 235
LEU A 246
 None
 1.46A 5izjB-2cw5A:
undetectable		 5izjB-2cw5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 5 LEU A  45
ALA A  49
LEU A  52
LEU A 179
 None
 0.81A 5vkqA-2cw5A:
undetectable
5vkqD-2cw5A:
undetectable		 5vkqA-2cw5A:
9.79
5vkqD-2cw5A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 5 LEU A 179
LEU A  45
ALA A  49
LEU A  52
 None
 0.84A 5vkqA-2cw5A:
undetectable
5vkqB-2cw5A:
undetectable		 5vkqA-2cw5A:
9.79
5vkqB-2cw5A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 5 LEU A 179
LEU A  45
ALA A  49
LEU A  52
 None
 0.86A 5vkqB-2cw5A:
undetectable
5vkqC-2cw5A:
undetectable		 5vkqB-2cw5A:
9.79
5vkqC-2cw5A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG
(Thermus
thermophilus) 		4 / 5 LEU A 179
LEU A  45
ALA A  49
LEU A  52
 None
 0.84A 5vkqC-2cw5A:
undetectable
5vkqD-2cw5A:
undetectable		 5vkqC-2cw5A:
9.79
5vkqD-2cw5A:
9.79