SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 9 LEU A 263
GLY A  43
ALA A 261
LEU A 299
ALA A 302
LEU A  63
 None
 1.13A 1muoA-2cw6A:
undetectable		 1muoA-2cw6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLU A  72
VAL A  38
GLU A 199
ASP A 257
 None
 1.29A 1s3zA-2cw6A:
undetectable
1s3zB-2cw6A:
undetectable		 1s3zA-2cw6A:
19.67
1s3zB-2cw6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 322
SER A 316
VAL A 260
MET A  62
 None
 1.11A 1tv8A-2cw6A:
4.9		 1tv8A-2cw6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 322
SER A 316
VAL A 260
MET A  62
 None
 1.16A 1tv8B-2cw6A:
5.1		 1tv8B-2cw6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 322
SER A 316
VAL A 260
MET A  62
 None
 1.23A 2fb2B-2cw6A:
6.1		 2fb2B-2cw6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A  67
ILE A  35
THR A 278
LEU A  63
 None
 1.02A 2xrhA-2cw6A:
0.6		 2xrhA-2cw6A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A  38
SER A 163
VAL A 255
VAL A  70
 None
 1.16A 2y05A-2cw6A:
undetectable
2y05B-2cw6A:
undetectable		 2y05A-2cw6A:
22.22
2y05B-2cw6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A  42
THR A 292
GLU A  37
 MG  A 401 (-2.5A)
None
None
 0.77A 2zifB-2cw6A:
undetectable		 2zifB-2cw6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ASN A 275
GLY A 264
GLY A 265
GLY A  43
ASP A  42
 MG  A 401 (-2.8A)
None
None
None
MG  A 401 (-2.5A)
 1.34A 3ztvA-2cw6A:
2.0		 3ztvA-2cw6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ASP A  42
LEU A  68
GLY A  43
VAL A  38
LEU A  63
GLY A 274
 MG  A 401 (-2.5A)
None
None
None
None
None
 1.45A 4dc3B-2cw6A:
3.1		 4dc3B-2cw6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ASN A 275
GLY A 264
GLY A 265
GLY A  43
ASP A  42
 MG  A 401 (-2.8A)
None
None
None
MG  A 401 (-2.5A)
 1.35A 4h2fA-2cw6A:
3.0		 4h2fA-2cw6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ASN A 275
GLY A 264
GLY A 265
GLY A  43
ASP A  42
 MG  A 401 (-2.8A)
None
None
None
MG  A 401 (-2.5A)
 1.27A 4h2gA-2cw6A:
2.1		 4h2gA-2cw6A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A 117
GLY A 120
LYS A 122
 None
 0.75A 4k50A-2cw6A:
undetectable		 4k50A-2cw6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A 117
GLY A 120
LYS A 122
 None
 0.78A 4k50I-2cw6A:
undetectable		 4k50I-2cw6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 219
MET A 222
ASP A 204
 None
 0.92A 4mm4B-2cw6A:
0.0		 4mm4B-2cw6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.06A 4otyA-2cw6A:
undetectable		 4otyA-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 THR A 237
GLY A 264
ASP A  42
SER A 273
 None
None
MG  A 401 (-2.5A)
None
 1.13A 4rfqA-2cw6A:
undetectable		 4rfqA-2cw6A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
GLY A 262
ALA A 277
SER A 258
LEU A 276
 None
 1.11A 4rrwA-2cw6A:
undetectable		 4rrwA-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.11A 4rrwA-2cw6A:
undetectable		 4rrwA-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.05A 4rrwD-2cw6A:
undetectable		 4rrwD-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
GLY A 262
ALA A 277
SER A 258
LEU A 276
 None
 1.11A 4rrzA-2cw6A:
undetectable		 4rrzA-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.11A 4rrzA-2cw6A:
undetectable		 4rrzA-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.05A 4rrzD-2cw6A:
undetectable		 4rrzD-2cw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 286
THR A 292
THR A 245
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.29A 5axaA-2cw6A:
undetectable		 5axaA-2cw6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 286
THR A 292
THR A 245
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.31A 5axaC-2cw6A:
undetectable		 5axaC-2cw6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A  35
VAL A  36
SER A 258
VAL A 221
LEU A 230
 None
 1.14A 5ergB-2cw6A:
undetectable		 5ergB-2cw6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A  43
SER A 259
VAL A  38
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.12A 5ewuA-2cw6A:
undetectable		 5ewuA-2cw6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A  43
SER A 259
VAL A  38
HIS A 235
 None
None
None
MG  A 401 (-3.2A)
 1.07A 5ewuB-2cw6A:
undetectable		 5ewuB-2cw6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.03A 5ikrA-2cw6A:
undetectable		 5ikrA-2cw6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
 None
 1.04A 5ikrB-2cw6A:
undetectable		 5ikrB-2cw6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 SER A 142
SER A 146
VAL A 188
LYS A 184
SER A 169
 None
 0.98A 5l5fK-2cw6A:
0.0
5l5fL-2cw6A:
0.0		 5l5fK-2cw6A:
21.04
5l5fL-2cw6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 142
SER A 146
LYS A 184
SER A 169
 None
 1.05A 5l5fY-2cw6A:
undetectable
5l5fZ-2cw6A:
undetectable		 5l5fY-2cw6A:
21.04
5l5fZ-2cw6A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A 257
GLU A  72
THR A 135
ARG A 165
GLY A 166
 None
 1.06A 5m5cB-2cw6A:
2.7		 5m5cB-2cw6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 147
CYH A 170
THR A 205
PHE A 134
 None
 1.47A 5mwyA-2cw6A:
undetectable		 5mwyA-2cw6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A  55
LYS A  58
VAL A 260
ASN A 304
 None
 1.31A 5vc3A-2cw6A:
undetectable		 5vc3A-2cw6A:
21.92