SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 12 VAL A 503
ILE A  90
TYR A  75
SER A  94
LEU A 114
 None
None
SO4  A1001 (-4.6A)
SO4  A1001 (-3.1A)
None
 1.15A 1fm4A-2cw7A:
undetectable		 1fm4A-2cw7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 TYR A 188
GLY A 167
MET A 168
LEU A 169
 None
 0.66A 1qzzA-2cw7A:
undetectable		 1qzzA-2cw7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 PHE A 363
LEU A 278
LEU A 137
LEU A 140
 None
 0.99A 2bfpB-2cw7A:
undetectable		 2bfpB-2cw7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 LEU A 532
TYR A 534
LEU A 128
LEU A  11
 None
 0.94A 2bfpC-2cw7A:
undetectable		 2bfpC-2cw7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 THR A 366
PRO A 368
PRO A 129
 None
 0.84A 2d55C-2cw7A:
undetectable		 2d55C-2cw7A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 ASN A 349
ILE A 272
MET A 268
 None
 0.82A 2h42C-2cw7A:
undetectable		 2h42C-2cw7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 12 LEU A  98
GLY A 529
VAL A 122
GLY A  87
VAL A 120
 None
 0.94A 2ieoA-2cw7A:
undetectable		 2ieoA-2cw7A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 5 GLY A 104
TRP A 492
ARG A 489
LEU A 490
 None
 1.31A 2j2pD-2cw7A:
undetectable
2j2pF-2cw7A:
0.5		 2j2pD-2cw7A:
17.14
2j2pF-2cw7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 11 LEU A 106
LEU A 114
VAL A 120
ILE A  92
VAL A 533
 None
 1.21A 2uxoB-2cw7A:
undetectable		 2uxoB-2cw7A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 7 LEU A 281
PHE A 326
ILE A 272
GLY A 283
 None
 0.84A 2v0mC-2cw7A:
undetectable		 2v0mC-2cw7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 VAL A 364
GLU A 276
ALA A 374
PRO A 368
 None
 1.13A 2v41G-2cw7A:
undetectable
2v41H-2cw7A:
undetectable		 2v41G-2cw7A:
17.44
2v41H-2cw7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 11 ALA A 279
LEU A 282
ILE A 360
PRO A 361
SER A 367
 None
 1.17A 3bpxA-2cw7A:
3.5
3bpxB-2cw7A:
undetectable		 3bpxA-2cw7A:
16.32
3bpxB-2cw7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 LYS A 256
TYR A 188
MET A 250
GLU A 257
 None
 1.30A 3dh0A-2cw7A:
undetectable		 3dh0A-2cw7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 GLU A 113
SER A 100
VAL A 120
 None
 0.81A 3eeoA-2cw7A:
undetectable		 3eeoA-2cw7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 9 GLU A  12
LEU A  50
VAL A  10
ILE A  25
LEU A 518
 None
 1.37A 3fl9H-2cw7A:
undetectable		 3fl9H-2cw7A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 PHE A 347
TYR A 284
LEU A 354
 None
 0.79A 3keeB-2cw7A:
undetectable		 3keeB-2cw7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 6 VAL A 101
LEU A 527
ILE A  92
ALA A 121
LEU A 500
 None
 1.39A 3kk6B-2cw7A:
undetectable		 3kk6B-2cw7A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 4 VAL A 498
PHE A  55
PHE A 526
VAL A 528
 None
 1.45A 3rv5C-2cw7A:
undetectable
3rv5D-2cw7A:
1.5		 3rv5C-2cw7A:
9.80
3rv5D-2cw7A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 5 PHE A 380
LEU A 282
LYS A 280
ARG A 372
 None
 1.49A 3sudD-2cw7A:
0.0		 3sudD-2cw7A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 VAL A 468
SER A 469
THR A 472
 None
 0.40A 4luhA-2cw7A:
undetectable		 4luhA-2cw7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 ASN A 410
VAL A 428
LEU A 419
GLY A 529
 None
 0.90A 4r3aA-2cw7A:
undetectable		 4r3aA-2cw7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 12 ALA A 445
TYR A 446
PHE A 436
GLY A 378
LEU A 394
 None
 1.22A 5fsaA-2cw7A:
undetectable		 5fsaA-2cw7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 THR A  93
SER A   1
ASP A  74
 SO4  A1001 (-3.9A)
SO4  A1001 ( 4.0A)
None
 0.83A 5kvaA-2cw7A:
undetectable		 5kvaA-2cw7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 THR A  93
SER A   1
ASP A  74
 SO4  A1001 (-3.9A)
SO4  A1001 ( 4.0A)
None
 0.82A 5kvaB-2cw7A:
undetectable		 5kvaB-2cw7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 9 LEU A 527
PRO A 123
GLY A 529
VAL A 406
LEU A 407
 None
 1.34A 5o96E-2cw7A:
undetectable
5o96F-2cw7A:
undetectable		 5o96E-2cw7A:
23.05
5o96F-2cw7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 12 LEU A 278
LEU A 281
GLY A 283
VAL A 286
LEU A 346
 None
 0.61A 5uc1A-2cw7A:
undetectable		 5uc1A-2cw7A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		5 / 12 LEU A 278
LEU A 281
GLY A 283
VAL A 286
LEU A 346
 None
 0.61A 5uc1B-2cw7A:
undetectable		 5uc1B-2cw7A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 THR A  93
PHE A 526
HIS A  73
ILE A  71
 SO4  A1001 (-3.9A)
None
None
None
 1.08A 5vkqB-2cw7A:
undetectable
5vkqC-2cw7A:
undetectable		 5vkqB-2cw7A:
17.05
5vkqC-2cw7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		4 / 8 LEU A 401
LEU A 400
LEU A 282
LYS A 358
 None
 0.93A 6ce2A-2cw7A:
undetectable		 6ce2A-2cw7A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 2cw7 ENDONUCLEASE
PI-PKOII
(Thermococcus
kodakarensis) 		3 / 3 TRP A 210
ILE A 175
GLU A 178
 None
 0.86A 6hcxA-2cw7A:
undetectable		 6hcxA-2cw7A:
10.36