SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 TRP A  52
THR A  33
GLY A  12
LEU A  10
 None
 1.00A 1gtiD-2cwaA:
undetectable		 1gtiD-2cwaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 TRP A  52
THR A  33
GLY A  12
LEU A  10
 None
 0.98A 1gtiE-2cwaA:
undetectable		 1gtiE-2cwaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 137
ARG A 189
LEU A 155
LEU A 223
ALA A 186
 None
 1.23A 2bxeA-2cwaA:
undetectable		 2bxeA-2cwaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 223
ARG A 189
LEU A 137
ALA A 186
 None
 1.07A 3b9mA-2cwaA:
undetectable		 3b9mA-2cwaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		5 / 8 LEU A 188
VAL A 196
LEU A 223
VAL A 175
LEU A 155
 None
 1.32A 3kp6A-2cwaA:
undetectable
3kp6B-2cwaA:
undetectable		 3kp6A-2cwaA:
17.87
3kp6B-2cwaA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 ILE A 197
LEU A  97
ILE A  99
PHE A 132
 None
 0.88A 4r38D-2cwaA:
undetectable		 4r38D-2cwaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 117
ARG A 212
ARG A  55
 None
 0.94A 5eajB-2cwaA:
undetectable		 5eajB-2cwaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 VAL A 218
HIS A 171
VAL A 159
 None
 0.62A 5jmnC-2cwaA:
undetectable		 5jmnC-2cwaA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 140
ARG A 189
LEU A 137
ASP A 192
 None
 0.92A 5tdzA-2cwaA:
undetectable		 5tdzA-2cwaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 7 HIS A 171
ASP A 102
GLY A  80
ASN A   6
 None
 0.97A 5x7pA-2cwaA:
undetectable		 5x7pA-2cwaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2cwa SINGLE-STRAND
BINDING PROTEIN
(Thermus
thermophilus) 		4 / 5 HIS A 171
ASP A 102
GLY A  80
ASN A   6
 None
 0.95A 5x7pB-2cwaA:
undetectable		 5x7pB-2cwaA:
12.18