SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 11 LEU A  88
LEU A 139
ALA A  21
PHE A  25
GLY A  23
 None
 1.05A 1cmaA-2cwdA:
undetectable
1cmaB-2cwdA:
undetectable		 1cmaA-2cwdA:
18.75
1cmaB-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 ALA A  21
PHE A  25
GLY A  23
LEU A  88
LEU A 139
 None
 1.04A 1cmcA-2cwdA:
undetectable
1cmcB-2cwdA:
undetectable		 1cmcA-2cwdA:
18.75
1cmcB-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 LEU A  88
LEU A 139
ALA A  21
PHE A  25
GLY A  23
 None
 1.04A 1cmcA-2cwdA:
undetectable
1cmcB-2cwdA:
undetectable		 1cmcA-2cwdA:
18.75
1cmcB-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ALA A  21
PHE A  25
GLY A  23
LEU A  88
LEU A 139
 None
 1.00A 1mj2A-2cwdA:
undetectable
1mj2B-2cwdA:
undetectable		 1mj2A-2cwdA:
18.75
1mj2B-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ALA A  21
PHE A  25
GLY A  23
LEU A  88
LEU A 139
 None
 0.97A 1mj2C-2cwdA:
undetectable
1mj2D-2cwdA:
undetectable		 1mj2C-2cwdA:
18.75
1mj2D-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ALA A  21
PHE A  25
GLY A  23
LEU A  88
LEU A 139
 None
 0.98A 1mjoC-2cwdA:
undetectable
1mjoD-2cwdA:
undetectable		 1mjoC-2cwdA:
18.75
1mjoD-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 11 LEU A  88
LEU A 139
ALA A  21
PHE A  25
GLY A  23
 None
 0.95A 1mjqA-2cwdA:
undetectable
1mjqB-2cwdA:
undetectable		 1mjqA-2cwdA:
18.75
1mjqB-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 LEU A  88
LEU A 139
ALA A  21
PHE A  25
GLY A  23
 None
 0.98A 1mjqC-2cwdA:
undetectable
1mjqD-2cwdA:
undetectable		 1mjqC-2cwdA:
18.75
1mjqD-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ALA A  21
PHE A  25
GLY A  23
LEU A  88
LEU A 139
 None
 0.98A 1mjqC-2cwdA:
undetectable
1mjqD-2cwdA:
undetectable		 1mjqC-2cwdA:
18.75
1mjqD-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 11 LEU A  88
LEU A 139
ALA A  21
PHE A  25
GLY A  23
 None
 0.98A 1mjqI-2cwdA:
undetectable
1mjqJ-2cwdA:
undetectable		 1mjqI-2cwdA:
18.75
1mjqJ-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ALA A  21
PHE A  25
GLY A  23
LEU A  88
LEU A 139
 None
 0.99A 1mjqI-2cwdA:
undetectable
1mjqJ-2cwdA:
undetectable		 1mjqI-2cwdA:
18.75
1mjqJ-2cwdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 11 ASP A  41
PRO A  19
MET A  20
GLY A  13
THR A  45
 MG  A1001 (-2.6A)
None
None
None
None
 1.47A 2uvnB-2cwdA:
undetectable		 2uvnB-2cwdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 8 VAL A  98
LEU A  99
ILE A  87
VAL A  89
ARG A 110
 None
 1.35A 3kp6A-2cwdA:
undetectable
3kp6B-2cwdA:
undetectable		 3kp6A-2cwdA:
21.43
3kp6B-2cwdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 ARG A 101
PHE A 102
PRO A 103
 None
 0.88A 3zoaB-2cwdA:
undetectable		 3zoaB-2cwdA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 0.98A 5ewuA-2cwdA:
undetectable		 5ewuA-2cwdA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 GLY A  44
THR A  45
SER A  18
VAL A  10
 None
 1.02A 5ewuB-2cwdA:
undetectable		 5ewuB-2cwdA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 VAL A  40
LEU A 139
MET A  54
GLY A  23
LEU A 147
 None
 1.22A 5x23A-2cwdA:
undetectable		 5x23A-2cwdA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 2cwd LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 VAL A 121
LEU A 116
LEU A 143
ILE A  24
ALA A  21
 None
 1.42A 5xprA-2cwdA:
undetectable		 5xprA-2cwdA:
15.09