SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ALA A  67
VAL A  71
TRP A  70
 None
 0.91A 1av2A-2cwfA:
undetectable
1av2B-2cwfA:
undetectable		 1av2A-2cwfA:
6.22
1av2B-2cwfA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ALA A  67
VAL A  71
TRP A  70
 None
 0.92A 1w5uA-2cwfA:
undetectable
1w5uB-2cwfA:
undetectable		 1w5uA-2cwfA:
6.22
1w5uB-2cwfA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 TRP A  70
ALA A  67
VAL A  71
 None
 0.92A 1w5uA-2cwfA:
undetectable
1w5uB-2cwfA:
undetectable		 1w5uA-2cwfA:
6.22
1w5uB-2cwfA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 HIS A 126
GLY A 275
ILE A 121
SER A 124
 NDP  A2510 (-4.0A)
None
None
None
 0.97A 2a8tB-2cwfA:
undetectable		 2a8tB-2cwfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 TRP A  70
ALA A  67
VAL A  71
 None
 0.88A 2izqC-2cwfA:
undetectable
2izqD-2cwfA:
undetectable		 2izqC-2cwfA:
6.22
2izqD-2cwfA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 TRP A  70
ALA A  67
VAL A  71
 None
 1.00A 3l8lA-2cwfA:
undetectable
3l8lB-2cwfA:
undetectable		 3l8lA-2cwfA:
6.22
3l8lB-2cwfA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 TRP A  70
ALA A  67
VAL A  71
 None
 0.79A 3l8lC-2cwfA:
undetectable
3l8lD-2cwfA:
undetectable		 3l8lC-2cwfA:
6.22
3l8lD-2cwfA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 275
ALA A 250
ILE A 121
ASP A  90
ALA A  91
 None
 0.75A 3nvkI-2cwfA:
undetectable		 3nvkI-2cwfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A  67
LEU A  66
VAL A  71
LEU A  39
ALA A  96
 None
 1.22A 3ozuA-2cwfA:
undetectable		 3ozuA-2cwfA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ARG A  88
GLY A 275
GLY A 255
SER A 150
ALA A 249
 None
None
None
NDP  A2510 (-4.2A)
None
 1.45A 3t7sC-2cwfA:
undetectable		 3t7sC-2cwfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 ILE A 327
VAL A  13
CYH A  43
HIS A  52
 None
 1.19A 4rzvA-2cwfA:
undetectable		 4rzvA-2cwfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 VAL A 280
ASP A 282
PRO A 283
ALA A 111
 None
 0.75A 5cu6A-2cwfA:
undetectable		 5cu6A-2cwfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 VAL A 280
ASP A 282
PRO A 283
ALA A 111
 None
 0.77A 5ospA-2cwfA:
undetectable		 5ospA-2cwfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 VAL A 280
ASP A 282
PRO A 283
ALA A 111
 None
 0.72A 5otrA-2cwfA:
undetectable		 5otrA-2cwfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 MET A 323
GLU A  41
ARG A  48
 None
 0.99A 5tjyA-2cwfA:
undetectable		 5tjyA-2cwfA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 MET A 323
GLU A  41
ARG A  48
 None
 0.94A 5tjzA-2cwfA:
undetectable		 5tjzA-2cwfA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 VAL A  82
LEU A 106
LEU A 119
ILE A 121
ALA A 120
 None
 1.25A 5xprA-2cwfA:
0.4		 5xprA-2cwfA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 ILE A 327
SER A 322
ALA A  46
LEU A  22
 None
 1.05A 6dwnA-2cwfA:
undetectable		 6dwnA-2cwfA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 HIS A  52
ARG A 321
HIS A 325
GLU A 318
 None
 0.89A 6mn4B-2cwfA:
undetectable		 6mn4B-2cwfA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 HIS A  52
ARG A 321
HIS A 325
GLU A 318
 None
 1.17A 6mn4D-2cwfA:
undetectable		 6mn4D-2cwfA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 HIS A  52
ARG A 321
HIS A 325
GLU A 318
 None
 1.04A 6mn4F-2cwfA:
undetectable		 6mn4F-2cwfA:
24.36