SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 11 PRO A  95
VAL A  23
VAL A 113
GLY A  25
LEU A 117
 None
 1.36A 1lwcA-2cwjA:
undetectable		 1lwcA-2cwjA:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		4 / 7 TYR A  11
ILE A  27
PRO A 106
GLU A 112
 None
 0.80A 1oniA-2cwjA:
18.8
1oniB-2cwjA:
19.3		 1oniA-2cwjA:
39.86
1oniB-2cwjA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		4 / 6 TYR A  11
ILE A  27
PRO A 106
GLU A 112
 None
 0.77A 1oniB-2cwjA:
19.3
1oniC-2cwjA:
19.3		 1oniB-2cwjA:
39.86
1oniC-2cwjA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		4 / 7 TYR A  11
ILE A  27
PRO A 106
GLU A 112
 None
 0.77A 1oniG-2cwjA:
19.3
1oniI-2cwjA:
19.2		 1oniG-2cwjA:
39.86
1oniI-2cwjA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		4 / 5 LEU A  49
GLY A  40
PRO A  28
ALA A  48
 None
 0.92A 2aohA-2cwjA:
undetectable		 2aohA-2cwjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		4 / 5 PRO A  31
ILE A  29
GLY A  34
LYS A   6
 None
 1.17A 2qeuA-2cwjA:
undetectable
2qeuC-2cwjA:
undetectable		 2qeuA-2cwjA:
25.17
2qeuC-2cwjA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		4 / 6 LEU A 111
ASP A  50
VAL A  23
ALA A 115
 None
 0.86A 4nkxA-2cwjA:
undetectable		 4nkxA-2cwjA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2cwj PUTATIVE
ENDONUCLEASE
(Aeropyrum
pernix) 		5 / 11 PRO A  95
VAL A  23
VAL A 113
GLY A  25
LEU A 117
 None
 1.37A 5hbmA-2cwjA:
undetectable		 5hbmA-2cwjA:
12.57