SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		5 / 12 VAL A 132
LEU A 125
LEU A 165
SER A 169
LEU A 173
 None
 1.39A 1mmkA-2cwoA:
undetectable		 1mmkA-2cwoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		5 / 11 VAL A 132
LEU A 125
LEU A 165
SER A 169
LEU A 173
 None
 1.37A 1mmtA-2cwoA:
undetectable		 1mmtA-2cwoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		3 / 3 THR A  10
LEU A  14
LEU A  21
 None
 0.47A 1mz9C-2cwoA:
undetectable		 1mz9C-2cwoA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 8 LEU A 137
PHE A 109
LEU A 173
SER A 154
 None
 0.84A 1wrlC-2cwoA:
undetectable
1wrlD-2cwoA:
undetectable		 1wrlC-2cwoA:
17.10
1wrlD-2cwoA:
17.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 8 LEU A 137
MET A 152
GLU A 150
HIS A  98
 None
 1.38A 3zmdA-2cwoA:
undetectable
3zmdB-2cwoA:
undetectable		 3zmdA-2cwoA:
33.64
3zmdB-2cwoA:
33.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 8 LEU A 165
SER A 169
THR A 101
ASP A 104
 None
 0.88A 4drjB-2cwoA:
2.1		 4drjB-2cwoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 6 PHE A 109
LEU A 137
HIS A 140
THR A  95
 None
 1.28A 4paeA-2cwoA:
undetectable		 4paeA-2cwoA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 6 LEU A 161
THR A 105
LEU A 163
SER A 164
 None
 1.05A 4pwjA-2cwoA:
undetectable		 4pwjA-2cwoA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 5 LEU A 161
LEU A 163
MET A 175
TYR A 155
 None
 1.29A 5uc3A-2cwoA:
undetectable		 5uc3A-2cwoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 6 ARG A 130
PHE A 109
ILE A 116
THR A 117
 None
 0.83A 5vceA-2cwoA:
undetectable		 5vceA-2cwoA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		4 / 6 ILE A  78
LEU A  46
ARG A  16
SER A  17
 None
 0.89A 6f6jA-2cwoA:
undetectable		 6f6jA-2cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2cwo RNA SILENCING
SUPPRESSOR
(Beet
yellows
virus) 		3 / 3 HIS A 139
ARG A 115
ILE A 116
 None
 0.63A 6fgdA-2cwoA:
undetectable		 6fgdA-2cwoA:
18.16