SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TRP A 125
ALA A 191
VAL A 170
 None
 0.85A 1bdwA-2cx9A:
undetectable
1bdwB-2cx9A:
undetectable		 1bdwA-2cx9A:
3.46
1bdwB-2cx9A:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 308
LEU A 306
GLU A 369
ALA A 254
 None
 0.87A 1ie4B-2cx9A:
undetectable
1ie4D-2cx9A:
undetectable		 1ie4B-2cx9A:
16.53
1ie4D-2cx9A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A  73
ARG A  69
ILE A 250
 None
 0.78A 1uobA-2cx9A:
undetectable		 1uobA-2cx9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.90A 2bm9C-2cx9A:
undetectable		 2bm9C-2cx9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.92A 2bm9D-2cx9A:
undetectable		 2bm9D-2cx9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.93A 2br4A-2cx9A:
undetectable		 2br4A-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.99A 2br4C-2cx9A:
undetectable		 2br4C-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 1.04A 2br4D-2cx9A:
undetectable		 2br4D-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.95A 2br4E-2cx9A:
undetectable		 2br4E-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  22
GLY A  83
TYR A  81
ALA A  86
ALA A  90
 None
 0.98A 2br4F-2cx9A:
undetectable		 2br4F-2cx9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A 282
GLN A 261
LEU A 264
SER A 288
LEU A 291
 None
 1.26A 2ceoB-2cx9A:
undetectable		 2ceoB-2cx9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A  78
VAL A  26
ALA A  30
THR A  88
LEU A 210
 None
 1.01A 2japA-2cx9A:
undetectable		 2japA-2cx9A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A  78
VAL A  26
ALA A  30
THR A  88
LEU A 210
 None
 1.00A 2japB-2cx9A:
undetectable		 2japB-2cx9A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A  78
VAL A  26
ALA A  30
THR A  88
LEU A 210
 None
 1.01A 2japC-2cx9A:
undetectable		 2japC-2cx9A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A  78
VAL A  26
ALA A  30
THR A  88
LEU A 210
 None
 1.00A 2japD-2cx9A:
undetectable		 2japD-2cx9A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ALA A  84
VAL A  89
PHE A  39
THR A 160
 None
 1.28A 2pkkA-2cx9A:
undetectable		 2pkkA-2cx9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 9 PHE A  71
ALA A  72
VAL A  75
GLU A  76
 None
 0.40A 2vufA-2cx9A:
2.1		 2vufA-2cx9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A  33
GLY A  37
SER A 163
 None
 0.50A 2xctB-2cx9A:
undetectable		 2xctB-2cx9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 GLU A 221
GLY A 154
THR A 155
GLU A 129
 None
 1.24A 3e9xA-2cx9A:
undetectable		 3e9xA-2cx9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 221
GLY A 154
THR A 155
 None
 0.58A 3iazA-2cx9A:
undetectable		 3iazA-2cx9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A  86
ILE A 252
SER A  91
GLY A 260
ALA A 262
 None
 1.15A 3lbdA-2cx9A:
undetectable		 3lbdA-2cx9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 GLY A 273
LEU A 291
ILE A 281
LEU A 344
 None
 0.86A 4o8fA-2cx9A:
undetectable		 4o8fA-2cx9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 191
GLY A 104
GLY A  98
LEU A 102
ALA A 107
 None
 0.80A 5c0oE-2cx9A:
undetectable		 5c0oE-2cx9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TYR A 305
GLY A 258
GLU A  76
ASP A 265
 None
 1.33A 5emlA-2cx9A:
undetectable		 5emlA-2cx9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  66
GLY A 247
ASP A 246
ARG A  69
LEU A  70
 None
 1.14A 5h5fA-2cx9A:
undetectable		 5h5fA-2cx9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU A  87
LEU A 364
GLY A 368
GLU A 369
 None
 1.24A 5hhjA-2cx9A:
undetectable		 5hhjA-2cx9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ILE A 100
PHE A 112
VAL A  57
GLU A 106
ALA A 111
 None
 1.09A 5lg3A-2cx9A:
2.5		 5lg3A-2cx9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A  14
ARG A  69
GLU A  11
ARG A  19
 None
 1.07A 5umwB-2cx9A:
undetectable
5umwE-2cx9A:
undetectable		 5umwB-2cx9A:
10.59
5umwE-2cx9A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A 282
ILE A 281
PHE A 277
GLY A 278
GLY A 273
 None
 1.34A 6awoA-2cx9A:
undetectable		 6awoA-2cx9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A 282
ILE A 281
PHE A 277
GLY A 278
GLY A 273
 None
 1.34A 6awqA-2cx9A:
undetectable		 6awqA-2cx9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLY A 258
ALA A  79
VAL A  26
LEU A  22
 None
 0.79A 6dwnB-2cx9A:
undetectable		 6dwnB-2cx9A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 2cx9 ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A 160
LEU A  95
VAL A 169
GLY A  83
ASN A  93
 None
 1.10A 6gngA-2cx9A:
undetectable		 6gngA-2cx9A:
23.10