SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 129
PHE A 102
VAL A 105
LEU A 120
MET A 304
 None
 1.41A 1e3vA-2cxeA:
0.0		 1e3vA-2cxeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 349
ALA A 371
ILE A 369
THR A 312
GLU A 325
 None
 1.20A 1vq1A-2cxeA:
undetectable		 1vq1A-2cxeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 TRP A 165
ARG A 202
PHE A 191
 None
 1.48A 1zeaH-2cxeA:
undetectable
1zeaL-2cxeA:
undetectable		 1zeaH-2cxeA:
19.26
1zeaL-2cxeA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A  20
LYS A  71
PRO A  21
ALA A  87
 None
 1.33A 2ejgA-2cxeA:
undetectable		 2ejgA-2cxeA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 326
GLU A 358
GLY A 317
LEU A 359
GLY A 321
 None
 1.40A 2fn1A-2cxeA:
undetectable		 2fn1A-2cxeA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 227
THR A 268
VAL A 249
ALA A 277
LEU A 261
 None
 1.06A 2m9qA-2cxeA:
undetectable		 2m9qA-2cxeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 4 VAL A 158
THR A 157
VAL A 375
GLY A 374
 None
 1.10A 2p2fB-2cxeA:
undetectable		 2p2fB-2cxeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 5 ARG A 328
MET A 295
THR A 294
LEU A 298
 None
 1.44A 3ag2J-2cxeA:
undetectable		 3ag2J-2cxeA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 10 VAL A 307
ILE A 227
MET A 264
PRO A 230
ILE A 253
 None
 1.26A 3clbD-2cxeA:
undetectable		 3clbD-2cxeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 351
ASP A 391
VAL A 375
THR A 157
 None
 1.20A 3cyxB-2cxeA:
undetectable		 3cyxB-2cxeA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A  32
TYR A  82
ALA A  42
LEU A  17
 None
 0.94A 3l4dA-2cxeA:
undetectable		 3l4dA-2cxeA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 5 VAL A 375
ILE A 369
MET A 250
ARG A 383
 None
 1.38A 3oezA-2cxeA:
undetectable		 3oezA-2cxeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 373
GLY A 372
MET A 376
GLY A 385
ILE A 182
 None
 1.27A 3v1nA-2cxeA:
undetectable		 3v1nA-2cxeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 11 VAL A 249
ILE A 225
TYR A 207
ARG A 210
PHE A 199
 None
 1.23A 3vawA-2cxeA:
undetectable		 3vawA-2cxeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 170
THR A 157
TYR A 223
TRP A 178
 None
 1.22A 3wipC-2cxeA:
undetectable
3wipD-2cxeA:
undetectable		 3wipC-2cxeA:
18.29
3wipD-2cxeA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 8 TRP A 178
TYR A 170
THR A 157
TYR A 223
 None
 1.21A 3wipA-2cxeA:
undetectable
3wipE-2cxeA:
undetectable		 3wipA-2cxeA:
18.29
3wipE-2cxeA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 224
ALA A 274
ILE A 275
LYS A 186
 None
 1.32A 4eixA-2cxeA:
undetectable		 4eixA-2cxeA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 224
MET A 250
ASP A 366
 None
 0.67A 4j7xB-2cxeA:
undetectable		 4j7xB-2cxeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 138
GLY A 139
LEU A 154
PHE A 146
MET A 147
 None
 1.35A 4xldA-2cxeA:
undetectable		 4xldA-2cxeA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 138
GLY A 139
LEU A 184
PHE A 146
MET A 147
 None
 1.20A 4xldA-2cxeA:
undetectable		 4xldA-2cxeA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 182
GLY A 180
ALA A 386
GLU A 219
THR A 157
 None
 1.24A 4xt8A-2cxeA:
2.1		 4xt8A-2cxeA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A 392
ALA A 388
LEU A 355
HIS A 352
VAL A 419
 None
 1.23A 5eb5A-2cxeA:
undetectable		 5eb5A-2cxeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 392
ALA A 388
LEU A 355
HIS A 352
VAL A 419
 None
 1.31A 5eb5B-2cxeA:
undetectable		 5eb5B-2cxeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 183
ARG A 390
ILE A 143
ILE A 397
ILE A 393
 None
 1.12A 5hw8A-2cxeA:
undetectable
5hw8D-2cxeA:
undetectable		 5hw8A-2cxeA:
15.09
5hw8D-2cxeA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 186
LEU A 206
ILE A 173
 None
 0.78A 5kc0A-2cxeA:
undetectable		 5kc0A-2cxeA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 7 SER A 415
THR A 157
ILE A 182
LEU A 177
 None
 0.95A 5te8C-2cxeA:
undetectable		 5te8C-2cxeA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 172
TYR A 175
ARG A 212
 None
 0.80A 5uunA-2cxeA:
undetectable		 5uunA-2cxeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 172
TYR A 175
ARG A 212
 None
 0.78A 5uunB-2cxeA:
undetectable		 5uunB-2cxeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		4 / 5 MET A 147
TYR A 248
GLY A 246
GLY A 245
 None
 1.20A 5x7pA-2cxeA:
undetectable		 5x7pA-2cxeA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 101
SER A 103
PHE A 102
 None
 0.64A 6fgcA-2cxeA:
2.1		 6fgcA-2cxeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 368
ALA A 156
GLN A 309
 None
 0.67A 6gb9A-2cxeA:
undetectable		 6gb9A-2cxeA:
22.44