SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 178
LEU A 182
ASP A  34
LEU A  35
LEU A 121
 None
 1.08A 1qzfA-2cxhA:
undetectable		 1qzfA-2cxhA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 178
LEU A 182
ASP A  34
LEU A  35
LEU A 121
 None
 1.07A 1qzfB-2cxhA:
2.2		 1qzfB-2cxhA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 178
LEU A 182
ASP A  34
LEU A  35
LEU A 121
 None
 1.07A 1qzfC-2cxhA:
2.9		 1qzfC-2cxhA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 178
LEU A 182
ASP A  34
LEU A  35
LEU A 121
 None
 1.08A 1qzfD-2cxhA:
2.9		 1qzfD-2cxhA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 178
LEU A 182
ASP A  34
LEU A  35
LEU A 121
 None
 1.07A 1qzfE-2cxhA:
2.9		 1qzfE-2cxhA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 11 ALA A 123
VAL A 169
ILE A  39
LEU A  35
PHE A 171
 None
 1.32A 3fl9C-2cxhA:
undetectable		 3fl9C-2cxhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 9 ALA A 123
VAL A 169
ILE A  39
LEU A  35
PHE A 171
 None
 1.32A 3fl9H-2cxhA:
undetectable		 3fl9H-2cxhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		3 / 3 SER A  21
GLY A  71
SER A  25
 None
 0.58A 3loqA-2cxhA:
undetectable		 3loqA-2cxhA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		4 / 8 GLY A  63
ALA A  64
ASP A  65
GLY A  41
 None
 0.69A 3so9A-2cxhA:
undetectable		 3so9A-2cxhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 10 ALA A 137
VAL A 167
ALA A 157
ALA A 123
ILE A 159
 None
 1.00A 4lbgA-2cxhA:
undetectable		 4lbgA-2cxhA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 9 ALA A 137
VAL A 167
ALA A 157
ALA A 123
ILE A 159
 None
 1.01A 4lbgB-2cxhA:
undetectable		 4lbgB-2cxhA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		4 / 5 LEU A  17
ASP A  65
ARG A  66
ILE A  94
 None
 1.41A 4mwrA-2cxhA:
undetectable		 4mwrA-2cxhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		4 / 8 LEU A  17
VAL A  85
TYR A  83
LEU A  55
 None
 1.02A 4puoC-2cxhA:
undetectable		 4puoC-2cxhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		3 / 3 LEU A  35
LEU A 182
ARG A 109
 None
 0.48A 5hnzB-2cxhA:
undetectable		 5hnzB-2cxhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN
(Aeropyrum
pernix) 		5 / 12 VAL A 191
ALA A 141
PHE A 142
GLY A 185
LEU A 184
 None
 1.24A 5m54E-2cxhA:
undetectable		 5m54E-2cxhA:
19.86