SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 10 PRO A 214
VAL A 140
ILE A 154
TYR A 106
PRO A 200
 None
 1.32A 13gsA-2cxiA:
undetectable		 13gsA-2cxiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 9 PRO A 214
VAL A 140
ILE A 154
TYR A 106
PRO A 200
 None
 1.32A 13gsB-2cxiA:
undetectable		 13gsB-2cxiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 7 ASP A 331
ASP A 330
TYR A 312
TYR A 325
 None
 1.44A 1cebA-2cxiA:
undetectable		 1cebA-2cxiA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 ARG A  56
ALA A  31
ASP A  58
GLY A  64
 None
 1.15A 1e7cA-2cxiA:
undetectable		 1e7cA-2cxiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 112
ASP A 115
LEU A 119
LEU A 114
 None
 1.08A 1e7cA-2cxiA:
undetectable		 1e7cA-2cxiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A 114
THR A 228
GLY A 111
LEU A 254
 None
 0.93A 1gtiA-2cxiA:
undetectable		 1gtiA-2cxiA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 8 SER A 211
ILE A 233
VAL A  91
SER A  87
 None
 0.96A 1kb9A-2cxiA:
3.2
1kb9C-2cxiA:
undetectable
1kb9D-2cxiA:
undetectable
1kb9E-2cxiA:
undetectable		 1kb9A-2cxiA:
21.94
1kb9C-2cxiA:
23.15
1kb9D-2cxiA:
20.05
1kb9E-2cxiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 291
GLY A 319
ASP A 300
 None
 0.49A 1kf6A-2cxiA:
undetectable
1kf6B-2cxiA:
undetectable		 1kf6A-2cxiA:
20.85
1kf6B-2cxiA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 11 VAL A 266
VAL A  93
TYR A 156
GLU A 274
LEU A 247
 None
 1.35A 1t6zB-2cxiA:
undetectable		 1t6zB-2cxiA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 TYR A 103
TYR A 268
ILE A 273
GLY A 237
 None
 1.37A 2du8G-2cxiA:
undetectable		 2du8G-2cxiA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 TYR A 103
TYR A 268
ILE A 273
GLY A 237
 None
 1.30A 2du8J-2cxiA:
undetectable		 2du8J-2cxiA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 10 GLY A 169
LEU A 168
ILE A 216
PHE A 165
ARG A 223
 None
 0.83A 2f8dA-2cxiA:
undetectable		 2f8dA-2cxiA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 10 GLY A 169
LEU A 168
ILE A 216
PHE A 165
ARG A 223
 None
 0.81A 2f8dB-2cxiA:
undetectable		 2f8dB-2cxiA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 THR A 236
GLY A 143
ILE A 123
LEU A 247
MET A 250
 None
 1.17A 3fzgA-2cxiA:
undetectable		 3fzgA-2cxiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 329
ARG A  56
ASP A  53
LYS A  32
 None
 1.15A 3jqzA-2cxiA:
0.7		 3jqzA-2cxiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 108
THR A 275
LEU A 247
VAL A  91
VAL A 266
 None
 1.04A 4c9lA-2cxiA:
undetectable		 4c9lA-2cxiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 108
THR A 275
LEU A 247
VAL A  91
VAL A 266
 None
 1.04A 4c9lB-2cxiA:
undetectable		 4c9lB-2cxiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 108
THR A 275
LEU A 247
VAL A  91
VAL A 266
 None
 1.06A 4c9oA-2cxiA:
undetectable		 4c9oA-2cxiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 108
THR A 275
LEU A 247
VAL A  91
VAL A 266
 None
 1.04A 4c9oB-2cxiA:
undetectable		 4c9oB-2cxiA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		3 / 3 PRO A 200
MET A 212
TYR A 199
 None
 1.13A 4qa0B-2cxiA:
undetectable		 4qa0B-2cxiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 7 TYR A 289
VAL A 285
ILE A 332
LEU A 343
 None
 1.17A 4xo7B-2cxiA:
undetectable		 4xo7B-2cxiA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  75
LEU A  73
GLY A  16
ILE A  15
GLY A 258
 None
 0.94A 5d4uD-2cxiA:
undetectable		 5d4uD-2cxiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 TRP A  71
TYR A  82
GLU A 256
TYR A 348
 None
 1.39A 6ep4A-2cxiA:
undetectable		 6ep4A-2cxiA:
12.66