SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 TRP A 505
ALA A   3
VAL A 371
 None
 0.96A 1bdwA-2cxnA:
undetectable
1bdwB-2cxnA:
undetectable		 1bdwA-2cxnA:
4.32
1bdwB-2cxnA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 11 PHE A 264
LEU A 246
LEU A 286
VAL A 253
LEU A 205
 None
 1.02A 1dtlA-2cxnA:
undetectable		 1dtlA-2cxnA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 10 MET A  65
LEU A  68
LEU A  71
ALA A  72
LEU A 319
 None
 0.93A 1gwrA-2cxnA:
undetectable		 1gwrA-2cxnA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 8 ASN A 508
ILE A 507
GLY A 502
GLY A 355
 None
 0.75A 1me7A-2cxnA:
undetectable		 1me7A-2cxnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 VAL A  98
ASN A 508
TRP A 513
 None
 0.81A 2y00B-2cxnA:
undetectable		 2y00B-2cxnA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 ARG A 273
GLY A 502
ILE A 325
ASP A 506
ASN A 329
 None
 1.12A 3a25A-2cxnA:
undetectable		 3a25A-2cxnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 8 HIS A 100
VAL A 122
LEU A 126
ARG A 104
LEU A 297
 None
 1.22A 3kp6A-2cxnA:
undetectable
3kp6B-2cxnA:
undetectable		 3kp6A-2cxnA:
13.42
3kp6B-2cxnA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 LEU A  13
TYR A 331
TYR A 327
TRP A 326
LEU A  68
 None
 1.34A 3medA-2cxnA:
undetectable
3medB-2cxnA:
undetectable		 3medA-2cxnA:
20.77
3medB-2cxnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 7 ARG A 104
ALA A 300
TRP A 302
ALA A 492
 None
 1.09A 3tx2A-2cxnA:
undetectable		 3tx2A-2cxnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 8 ILE A 325
LEU A 322
VAL A  77
GLY A  76
 None
 0.83A 3w1wA-2cxnA:
2.5		 3w1wA-2cxnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 VAL A 125
PHE A 293
ILE A 491
VAL A 270
VAL A 122
 None
 0.96A 3w68D-2cxnA:
undetectable		 3w68D-2cxnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 7 PHE A 348
VAL A 167
GLY A 488
PHE A 352
 None
 0.86A 4ejjB-2cxnA:
undetectable		 4ejjB-2cxnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 ASP A 356
ALA A 321
TRP A 505
MET A  84
PHE A 510
 None
 1.27A 4iaqA-2cxnA:
undetectable		 4iaqA-2cxnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 ASP A 356
ALA A 321
TRP A 505
MET A  84
PHE A 510
 None
 1.27A 4iarA-2cxnA:
undetectable		 4iarA-2cxnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 GLY A 332
HIS A 336
THR A 335
MET A 401
ILE A 402
 None
 1.29A 4okwA-2cxnA:
undetectable		 4okwA-2cxnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 10 ALA A 209
LEU A 162
LEU A 165
PHE A 183
THR A 168
 None
 1.27A 4zmeB-2cxnA:
undetectable		 4zmeB-2cxnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 8 LEU A  71
MET A  67
HIS A  17
LEU A  14
 None
 1.08A 5dxeA-2cxnA:
undetectable		 5dxeA-2cxnA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 ILE A 491
ALA A 492
GLY A 299
GLY A 163
VAL A 167
 None
 1.20A 5i71A-2cxnA:
undetectable		 5i71A-2cxnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 GLY A 189
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.24A 5igyA-2cxnA:
undetectable		 5igyA-2cxnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 GLY A 189
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.21A 5ih0A-2cxnA:
undetectable		 5ih0A-2cxnA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 GLY A 271
GLY A 272
GLN A 512
 None
 0.39A 5imsA-2cxnA:
4.7		 5imsA-2cxnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 THR A 168
PHE A 206
ALA A 225
SER A 160
ILE A 157
 None
None
None
PO4  A1601 (-2.7A)
None
 1.32A 5iwuA-2cxnA:
undetectable		 5iwuA-2cxnA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 ARG A 104
LEU A 490
ALA A 170
GLY A 299
ALA A 300
 None
 0.90A 5jw1B-2cxnA:
undetectable		 5jw1B-2cxnA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 LYS A 362
LEU A   4
ILE A 328
 None
 0.73A 5kc4A-2cxnA:
1.0		 5kc4A-2cxnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 12 TYR A 494
LEU A  44
ALA A 316
LEU A 319
ILE A 477
 None
 1.29A 5ljcA-2cxnA:
undetectable		 5ljcA-2cxnA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		5 / 9 ALA A 193
LEU A 199
ILE A 153
ILE A 155
ASN A 221
 None
 1.00A 5nunA-2cxnA:
undetectable		 5nunA-2cxnA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 5 GLN A 432
THR A 433
HIS A 336
LEU A 339
 None
 1.22A 6aphA-2cxnA:
3.4		 6aphA-2cxnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
PO4  A1601 ( 4.7A)
None
 0.71A 6baaE-2cxnA:
0.0		 6baaE-2cxnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
PO4  A1601 ( 4.7A)
None
 0.71A 6baaF-2cxnA:
0.0		 6baaF-2cxnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
PO4  A1601 ( 4.7A)
None
 0.72A 6baaG-2cxnA:
undetectable		 6baaG-2cxnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
PO4  A1601 ( 4.7A)
None
 0.72A 6baaH-2cxnA:
undetectable		 6baaH-2cxnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 6 SER A 160
ALA A 279
SER A 278
ALA A 209
 PO4  A1601 (-2.7A)
None
None
None
 0.80A 6bocA-2cxnA:
undetectable
6bocB-2cxnA:
undetectable
6bocC-2cxnA:
undetectable
6bocD-2cxnA:
undetectable		 6bocA-2cxnA:
4.28
6bocB-2cxnA:
4.28
6bocC-2cxnA:
4.28
6bocD-2cxnA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 8 LEU A  71
MET A  67
HIS A  17
LEU A  14
 None
 1.09A 6cbzA-2cxnA:
undetectable		 6cbzA-2cxnA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		3 / 3 TYR A 144
HIS A 242
PHE A 229
 None
 1.05A 6esmA-2cxnA:
undetectable		 6esmA-2cxnA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 6 GLU A 460
ARG A 446
VAL A 467
PRO A 442
 None
 1.30A 6fgdA-2cxnA:
2.7		 6fgdA-2cxnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mus
musculus) 		4 / 5 GLN A 432
THR A 433
HIS A 336
LEU A 339
 None
 1.22A 6gbnB-2cxnA:
3.3		 6gbnB-2cxnA:
22.05