SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		5 / 11 LEU A 118
ALA A  80
ILE A  49
THR A 125
ILE A 123
 None
 0.97A 1c6yA-2cxxA:
undetectable		 1c6yA-2cxxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		4 / 8 ILE A 163
LEU A  17
ILE A 126
GLY A   8
 None
 0.85A 4hb8A-2cxxA:
undetectable		 4hb8A-2cxxA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		5 / 10 LEU A 118
ALA A  80
ILE A  49
THR A 125
ILE A 123
 None
 0.92A 4njuB-2cxxA:
undetectable		 4njuB-2cxxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		5 / 10 LEU A 118
ALA A  80
ILE A  49
THR A 125
ILE A 123
 None
 0.92A 4njuD-2cxxA:
undetectable		 4njuD-2cxxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		4 / 7 PRO A 109
GLU A 103
GLU A 150
ASP A 122
 None
 1.26A 4uacA-2cxxA:
undetectable		 4uacA-2cxxA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		4 / 8 ILE A   5
ALA A   2
THR A   3
HIS A  46
 None
 0.90A 5ecnD-2cxxA:
1.5		 5ecnD-2cxxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		3 / 3 ARG A 183
ARG A 177
ARG A 185
 None
 0.71A 5vcgA-2cxxA:
undetectable		 5vcgA-2cxxA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2cxx PROBABLE GTP-BINDING
PROTEIN ENGB
(Pyrococcus
horikoshii) 		4 / 5 VAL A  73
PHE A  56
MET A  57
GLY A  59
 None
 1.37A 6hd4A-2cxxA:
undetectable		 6hd4A-2cxxA:
20.69